Chemoenzymatic approaches to the montanine alkaloids: A total synthesis of (+)-brunsvigine

Martin G. Banwell; Okanya J. Kokas; Anthony C. Willis

doi:10.1021/ol071344y

Chemoenzymatic approaches to the montanine alkaloids: A total synthesis of (+)-brunsvigine

Martin G. Banwell^*
, Okanya J. Kokas
, Anthony C. Willis

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

63 Citations (Scopus)

Abstract

The readily available and enzymatically derived cis-1,2-dihydrocatechols 3a and 3b have been elaborated over 17 steps, including a novel radical addition/elimination sequence, into the enantiomer, (+)-1, of the montanine alkaloid brunsvigine [(-)-1].

Original language	English
Pages (from-to)	3503-3506
Number of pages	4
Journal	Organic Letters
Volume	9
Issue number	18
DOIs	https://doi.org/10.1021/ol071344y
Publication status	Published - 30 Aug 2007

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title = "Chemoenzymatic approaches to the montanine alkaloids: A total synthesis of (+)-brunsvigine",

abstract = "The readily available and enzymatically derived cis-1,2-dihydrocatechols 3a and 3b have been elaborated over 17 steps, including a novel radical addition/elimination sequence, into the enantiomer, (+)-1, of the montanine alkaloid brunsvigine [(-)-1].",

author = "Banwell, \{Martin G.\} and Kokas, \{Okanya J.\} and Willis, \{Anthony C.\}",

year = "2007",

month = aug,

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doi = "10.1021/ol071344y",

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T2 - A total synthesis of (+)-brunsvigine

AU - Banwell, Martin G.

AU - Kokas, Okanya J.

AU - Willis, Anthony C.

PY - 2007/8/30

Y1 - 2007/8/30

N2 - The readily available and enzymatically derived cis-1,2-dihydrocatechols 3a and 3b have been elaborated over 17 steps, including a novel radical addition/elimination sequence, into the enantiomer, (+)-1, of the montanine alkaloid brunsvigine [(-)-1].

AB - The readily available and enzymatically derived cis-1,2-dihydrocatechols 3a and 3b have been elaborated over 17 steps, including a novel radical addition/elimination sequence, into the enantiomer, (+)-1, of the montanine alkaloid brunsvigine [(-)-1].

UR - https://www.scopus.com/pages/publications/34548534948

U2 - 10.1021/ol071344y

DO - 10.1021/ol071344y

M3 - Article

SN - 1523-7060

VL - 9

SP - 3503

EP - 3506

JO - Organic Letters

JF - Organic Letters

IS - 18

ER -

Chemoenzymatic approaches to the montanine alkaloids: A total synthesis of (+)-brunsvigine

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