Chemoenzymatic pathways for the synthesis of biologically active natural products

Martin Banwell, Benoit Bolte, Joshua Buckler, Ee Chang, Ping Lan, Ehab Taher, Lorenzo White, Anthony Willis

    Research output: Contribution to journalArticlepeer-review


    The whole-cell biotransformation of mono-nuclear aromatic compounds using certain genetically-engineered micro-organisms that over-express the enzyme toluene dioxygenase (TDO) allows for the large scale production of compounds known as cis-1,2-dihydrocatechols. These metabolites, which are normally obtained in enantiomerically pure form, can be manipulated, by chemical means, in a range of distinct (and predictable) ways with the result that they have proven to be especially versatile starting materials for the assembly of a range of structurally diverse and biologically active systems. Herein we describe, on a case-by-case basis, the recent applications of various combinations of TDO-mediated and chemical steps in so-called chemoenzymatic total syntheses of a range of organic compounds with therapeutic potential.
    Original languageEnglish
    Pages (from-to)34-50pp.
    JournalJournal and Proceedings of the Royal Society of New South Wales
    Issue numberPart 1-2
    Publication statusPublished - 2016


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