Chemoenzymatic Syntheses of Some Analogues of the Tricarbocyclic Core of the Anti-Bacterial Agent Platencin and the Biological Evaluation of Certain of their N-Arylpropionamide Derivatives

Rehmani N. Muhammad; Ee Ling Chang; Alistair G. Draffan; Anthony C. Willis; Paul D. Carr; Martin G. Banwell

doi:10.1071/CH18145

Chemoenzymatic Syntheses of Some Analogues of the Tricarbocyclic Core of the Anti-Bacterial Agent Platencin and the Biological Evaluation of Certain of their N-Arylpropionamide Derivatives

Rehmani N. Muhammad, Ee Ling Chang, Alistair G. Draffan, Anthony C. Willis, Paul D. Carr, Martin G. Banwell^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

A range of structural variations on the tricarbocyclic core 2 of the anti-bacterial agent platencin 1, including those represented by compounds 14, 15, and 27, have been prepared and certain of these elaborated, through substrate-controlled enolate alkylation reactions, to analogues of the natural product. Preliminary biological evaluation of these analogues revealed that they are only weakly active anti-infective agents.

Original language	English
Pages (from-to)	655-672
Number of pages	18
Journal	Australian Journal of Chemistry
Volume	71
Issue number	9
DOIs	https://doi.org/10.1071/CH18145
Publication status	Published - 2018

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10.1071/CH18145

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Muhammad, R. N., Chang, E. L., Draffan, A. G., Willis, A. C., Carr, P. D., & Banwell, M. G. (2018). Chemoenzymatic Syntheses of Some Analogues of the Tricarbocyclic Core of the Anti-Bacterial Agent Platencin and the Biological Evaluation of Certain of their N-Arylpropionamide Derivatives. Australian Journal of Chemistry, 71(9), 655-672. https://doi.org/10.1071/CH18145

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abstract = "A range of structural variations on the tricarbocyclic core 2 of the anti-bacterial agent platencin 1, including those represented by compounds 14, 15, and 27, have been prepared and certain of these elaborated, through substrate-controlled enolate alkylation reactions, to analogues of the natural product. Preliminary biological evaluation of these analogues revealed that they are only weakly active anti-infective agents.",

author = "Muhammad, {Rehmani N.} and Chang, {Ee Ling} and Draffan, {Alistair G.} and Willis, {Anthony C.} and Carr, {Paul D.} and Banwell, {Martin G.}",

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journal = "Australian Journal of Chemistry",

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Chemoenzymatic Syntheses of Some Analogues of the Tricarbocyclic Core of the Anti-Bacterial Agent Platencin and the Biological Evaluation of Certain of their N-Arylpropionamide Derivatives. / Muhammad, Rehmani N.; Chang, Ee Ling; Draffan, Alistair G. et al.
In: Australian Journal of Chemistry, Vol. 71, No. 9, 2018, p. 655-672.

Research output: Contribution to journal › Article › peer-review

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AU - Carr, Paul D.

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Chemoenzymatic Syntheses of Some Analogues of the Tricarbocyclic Core of the Anti-Bacterial Agent Platencin and the Biological Evaluation of Certain of their N-Arylpropionamide Derivatives

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