Chemokines in eosinophil-associated gastrointestinal disorders

Simon P. Hogan; Marc E. Rothenberg; Elizabeth Forbes; Vanessa E. Smart; Klaus I. Matthaei; Paul S. Foster

doi:10.1007/s11882-004-0047-8

Chemokines in eosinophil-associated gastrointestinal disorders

Simon P. Hogan^*, Marc E. Rothenberg, Elizabeth Forbes, Vanessa E. Smart, Klaus I. Matthaei, Paul S. Foster

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

28 Citations (Scopus)

Abstract

Eosinophil-associated gastrointestinal disorders (EGDs) are characterized by a pronounced cellular inflammation. Recent clinical and experimental investigations have implicated a family of molecules known as chemokines in the regulation of leukocyte recruitment in these diseases. The underlying cellular and molecular mechanisms involved in chemokine-mediated cellular infiltration are largely unknown. In this review, we describe the role of CD4+ T cells and eosinophils in the clinical manifestations of EGDs and discuss the current understanding of the role of chemokines in the recruitment of these cells in the expression of diseases.

Original language	English
Pages (from-to)	74-82
Number of pages	9
Journal	Current Allergy and Asthma Reports
Volume	4
Issue number	1
DOIs	https://doi.org/10.1007/s11882-004-0047-8
Publication status	Published - Jan 2004

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abstract = "Eosinophil-associated gastrointestinal disorders (EGDs) are characterized by a pronounced cellular inflammation. Recent clinical and experimental investigations have implicated a family of molecules known as chemokines in the regulation of leukocyte recruitment in these diseases. The underlying cellular and molecular mechanisms involved in chemokine-mediated cellular infiltration are largely unknown. In this review, we describe the role of CD4+ T cells and eosinophils in the clinical manifestations of EGDs and discuss the current understanding of the role of chemokines in the recruitment of these cells in the expression of diseases.",

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AU - Rothenberg, Marc E.

AU - Forbes, Elizabeth

AU - Smart, Vanessa E.

AU - Matthaei, Klaus I.

AU - Foster, Paul S.

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N2 - Eosinophil-associated gastrointestinal disorders (EGDs) are characterized by a pronounced cellular inflammation. Recent clinical and experimental investigations have implicated a family of molecules known as chemokines in the regulation of leukocyte recruitment in these diseases. The underlying cellular and molecular mechanisms involved in chemokine-mediated cellular infiltration are largely unknown. In this review, we describe the role of CD4+ T cells and eosinophils in the clinical manifestations of EGDs and discuss the current understanding of the role of chemokines in the recruitment of these cells in the expression of diseases.

AB - Eosinophil-associated gastrointestinal disorders (EGDs) are characterized by a pronounced cellular inflammation. Recent clinical and experimental investigations have implicated a family of molecules known as chemokines in the regulation of leukocyte recruitment in these diseases. The underlying cellular and molecular mechanisms involved in chemokine-mediated cellular infiltration are largely unknown. In this review, we describe the role of CD4+ T cells and eosinophils in the clinical manifestations of EGDs and discuss the current understanding of the role of chemokines in the recruitment of these cells in the expression of diseases.

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U2 - 10.1007/s11882-004-0047-8

DO - 10.1007/s11882-004-0047-8

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JO - Current Allergy and Asthma Reports

JF - Current Allergy and Asthma Reports

IS - 1

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Chemokines in eosinophil-associated gastrointestinal disorders

Abstract

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