Chemoselective Ligation Methods Based on the Concept of Native Chemical Ligation

L. R. Malins, R. J. Payne

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

This chapter extends from the earlier Science of Synthesis contribution on peptide synthesis (Section 21.11) and focuses on recent developments in chemoselective ligation chemistry based on the logic of native chemical ligation. Synthetic strategies that broaden the scope and versatility of the ligation reaction and that have been widely adopted for the preparation of homogeneous peptides and proteins are highlighted. Methods enabling the efficient preparation of peptide ligation precursors are also included in this chapter.

Original languageEnglish
Title of host publicationKnowledge Updates 2021/3
EditorsP.A. Clarke, J.A. Joule, S.P. Marsden, E.J. Petersson
PublisherGeorg Thieme Verlag
Pages193-241
Number of pages49
Edition3
ISBN (Electronic)9783132442092
DOIs
Publication statusPublished - 2021

Publication series

NameScience of Synthesis
Number3
Volume2021
ISSN (Print)2510-5469
ISSN (Electronic)2566-7297

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