Circular Dichroism Spectroscopy of Biomacromolecules

Alison Rodger

doi:10.1007/978-3-642-16712-6_638

Circular Dichroism Spectroscopy of Biomacromolecules

Alison Rodger^*

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Entry for encyclopedia/dictionary › peer-review

2 Citations (Scopus)

Abstract

Synonyms
Chiral Spectroscopy – Absorbance of circularly polarized light

Definition
Circular dichroism (CD) spectroscopy is now more widely used to study biological molecules than nonbiological ones (Berova et al. 2000; Nordén et al. 2010). This is despite the fact that the molecules concerned are typically DNAs and proteins which are large and that detailed structural analysis of their CD spectra is not possible (though work is in progress by both fitting algorithms (Wallace and Janes 2009) and calculations to enhance what can be deduced from the data).

The CD of biological macromolecules is mostly measured to investigate one of four things:

1. The conformation of the macromolecule itself

2. Changes in the conformation of the macromolecule

3. Interactions of the macromolecule with small molecules, especially achiral ones whose induced CD is due solely to their interaction with the macromolecule

4. The interactions between the macromolecule and other chiral molecules, including DNAs and...

Original language	English
Title of host publication	Encyclopedia of Biophysics
Editors	Gordon C. K. Roberts
Place of Publication	Berlin, Heidelberg
Publisher	Springer Science+Business Media B.V.
Pages	315-316
Number of pages	2
ISBN (Electronic)	9783642167126
ISBN (Print)	9783642167119
DOIs	https://doi.org/10.1007/978-3-642-16712-6_638
Publication status	Published - 2013
Externally published	Yes

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10.1007/978-3-642-16712-6_638

Cite this

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title = "Circular Dichroism Spectroscopy of Biomacromolecules",

abstract = "Synonyms Chiral Spectroscopy – Absorbance of circularly polarized light Definition Circular dichroism (CD) spectroscopy is now more widely used to study biological molecules than nonbiological ones (Berova et al. 2000; Nord{\'e}n et al. 2010). This is despite the fact that the molecules concerned are typically DNAs and proteins which are large and that detailed structural analysis of their CD spectra is not possible (though work is in progress by both fitting algorithms (Wallace and Janes 2009) and calculations to enhance what can be deduced from the data). The CD of biological macromolecules is mostly measured to investigate one of four things: 1. The conformation of the macromolecule itself 2. Changes in the conformation of the macromolecule 3. Interactions of the macromolecule with small molecules, especially achiral ones whose induced CD is due solely to their interaction with the macromolecule 4. The interactions between the macromolecule and other chiral molecules, including DNAs and...",

author = "Alison Rodger",

year = "2013",

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pages = "315--316",

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N2 - Synonyms Chiral Spectroscopy – Absorbance of circularly polarized light Definition Circular dichroism (CD) spectroscopy is now more widely used to study biological molecules than nonbiological ones (Berova et al. 2000; Nordén et al. 2010). This is despite the fact that the molecules concerned are typically DNAs and proteins which are large and that detailed structural analysis of their CD spectra is not possible (though work is in progress by both fitting algorithms (Wallace and Janes 2009) and calculations to enhance what can be deduced from the data). The CD of biological macromolecules is mostly measured to investigate one of four things: 1. The conformation of the macromolecule itself 2. Changes in the conformation of the macromolecule 3. Interactions of the macromolecule with small molecules, especially achiral ones whose induced CD is due solely to their interaction with the macromolecule 4. The interactions between the macromolecule and other chiral molecules, including DNAs and...

AB - Synonyms Chiral Spectroscopy – Absorbance of circularly polarized light Definition Circular dichroism (CD) spectroscopy is now more widely used to study biological molecules than nonbiological ones (Berova et al. 2000; Nordén et al. 2010). This is despite the fact that the molecules concerned are typically DNAs and proteins which are large and that detailed structural analysis of their CD spectra is not possible (though work is in progress by both fitting algorithms (Wallace and Janes 2009) and calculations to enhance what can be deduced from the data). The CD of biological macromolecules is mostly measured to investigate one of four things: 1. The conformation of the macromolecule itself 2. Changes in the conformation of the macromolecule 3. Interactions of the macromolecule with small molecules, especially achiral ones whose induced CD is due solely to their interaction with the macromolecule 4. The interactions between the macromolecule and other chiral molecules, including DNAs and...

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PB - Springer Science+Business Media B.V.

CY - Berlin, Heidelberg

ER -

Circular Dichroism Spectroscopy of Biomacromolecules

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