Cisplatin: Polymorphism and structural insights into an important chemotherapeutic drug

Valeska P. Ting; Marc Schmidtmann; Chick C. Wilson; Mark T. Weller

doi:10.1002/anie.201003185

Cisplatin: Polymorphism and structural insights into an important chemotherapeutic drug

Valeska P. Ting, Marc Schmidtmann, Chick C. Wilson, Mark T. Weller

Research output: Contribution to journal › Article › peer-review

37 Citations (Scopus)

Abstract

The changing face of cisplatin: The complete crystal structures, including the details of extensive intermolecular hydrogen bonding in two enantiotropic polymorphs of the chemotherapeutic drug cisplatin, have been elucidated. A massive thermal hysteresis effect exists between the two polymorphs, α and β, that are active at ambient temperatures.

Original language	English
Pages (from-to)	9408-9411
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	49
Issue number	49
DOIs	https://doi.org/10.1002/anie.201003185
Publication status	Published - 3 Dec 2010
Externally published	Yes

Access to Document

10.1002/anie.201003185

Cite this

@article{84b0b5ecaa52448383c706f17fcadaa6,

title = "Cisplatin: Polymorphism and structural insights into an important chemotherapeutic drug",

abstract = "The changing face of cisplatin: The complete crystal structures, including the details of extensive intermolecular hydrogen bonding in two enantiotropic polymorphs of the chemotherapeutic drug cisplatin, have been elucidated. A massive thermal hysteresis effect exists between the two polymorphs, α and β, that are active at ambient temperatures.",

keywords = "cisplatin, neutron diffraction, phase transitions, polymorphism",

author = "Ting, \{Valeska P.\} and Marc Schmidtmann and Wilson, \{Chick C.\} and Weller, \{Mark T.\}",

year = "2010",

month = dec,

day = "3",

doi = "10.1002/anie.201003185",

language = "English",

volume = "49",

pages = "9408--9411",

journal = "Angewandte Chemie - International Edition",

issn = "1433-7851",

publisher = "John Wiley \& Sons Ltd.",

number = "49",

}

TY - JOUR

T1 - Cisplatin

T2 - Polymorphism and structural insights into an important chemotherapeutic drug

AU - Ting, Valeska P.

AU - Schmidtmann, Marc

AU - Wilson, Chick C.

AU - Weller, Mark T.

PY - 2010/12/3

Y1 - 2010/12/3

N2 - The changing face of cisplatin: The complete crystal structures, including the details of extensive intermolecular hydrogen bonding in two enantiotropic polymorphs of the chemotherapeutic drug cisplatin, have been elucidated. A massive thermal hysteresis effect exists between the two polymorphs, α and β, that are active at ambient temperatures.

AB - The changing face of cisplatin: The complete crystal structures, including the details of extensive intermolecular hydrogen bonding in two enantiotropic polymorphs of the chemotherapeutic drug cisplatin, have been elucidated. A massive thermal hysteresis effect exists between the two polymorphs, α and β, that are active at ambient temperatures.

KW - cisplatin

KW - neutron diffraction

KW - phase transitions

KW - polymorphism

UR - http://www.scopus.com/inward/record.url?scp=78650160581&partnerID=8YFLogxK

U2 - 10.1002/anie.201003185

DO - 10.1002/anie.201003185

M3 - Article

SN - 1433-7851

VL - 49

SP - 9408

EP - 9411

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 49

ER -

Cisplatin: Polymorphism and structural insights into an important chemotherapeutic drug

Abstract

Access to Document

Other files and links

Fingerprint

Cite this