Class-Switch Recombination Occurs Infrequently in Germinal Centers

Jonathan A. Roco, Luka Mesin, Sebastian C. Binder, Christian Nefzger, Paula Gonzalez-Figueroa, Pablo F. Canete, Julia Ellyard, Qian Shen, Philippe A. Robert, Jean Cappello, Harpreet Vohra, Yang Zhang, Carla R. Nowosad, Arien Schiepers, Lynn M. Corcoran, Kai Michael Toellner, Jose M. Polo, Michael Meyer-Hermann, Gabriel D. Victora, Carola G. Vinuesa*

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    294 Citations (Scopus)

    Abstract

    Germinal centers (GCs) have long been considered sites in which Ig class-switch recombination (CSR) is favored. Roco et al. show that CSR occurs during the initial T cell:B cell interaction prior to GC formation and rapidly declines as B cells differentiate into GC cells and somatic hypermutation commences.

    Original languageEnglish
    Pages (from-to)337-350.e7
    JournalImmunity
    Volume51
    Issue number2
    DOIs
    Publication statusPublished - 20 Aug 2019

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