Class-Switch Recombination Occurs Infrequently in Germinal Centers

Jonathan A. Roco; Luka Mesin; Sebastian C. Binder; Christian Nefzger; Paula Gonzalez-Figueroa; Pablo F. Canete; Julia Ellyard; Qian Shen; Philippe A. Robert; Jean Cappello; Harpreet Vohra; Yang Zhang; Carla R. Nowosad; Arien Schiepers; Lynn M. Corcoran; Kai Michael Toellner; Jose M. Polo; Michael Meyer-Hermann; Gabriel D. Victora; Carola G. Vinuesa

doi:10.1016/j.immuni.2019.07.001

Class-Switch Recombination Occurs Infrequently in Germinal Centers

Jonathan A. Roco
, Luka Mesin
, Sebastian C. Binder
, Christian Nefzger
, Paula Gonzalez-Figueroa
, Pablo F. Canete
, Julia Ellyard
, Qian Shen
, Philippe A. Robert
, Jean Cappello
, Harpreet Vohra
, Yang Zhang
, Carla R. Nowosad
, Arien Schiepers
, Lynn M. Corcoran
, Kai Michael Toellner
, Jose M. Polo
, Michael Meyer-Hermann
, Gabriel D. Victora
, Carola G. Vinuesa^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

417 Citations (Scopus)

Abstract

Germinal centers (GCs) have long been considered sites in which Ig class-switch recombination (CSR) is favored. Roco et al. show that CSR occurs during the initial T cell:B cell interaction prior to GC formation and rapidly declines as B cells differentiate into GC cells and somatic hypermutation commences.

Original language	English
Pages (from-to)	337-350.e7
Journal	Immunity
Volume	51
Issue number	2
DOIs	https://doi.org/10.1016/j.immuni.2019.07.001
Publication status	Published - 20 Aug 2019

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10.1016/j.immuni.2019.07.001

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Roco, J. A., Mesin, L., Binder, S. C., Nefzger, C., Gonzalez-Figueroa, P., Canete, P. F., Ellyard, J., Shen, Q., Robert, P. A., Cappello, J., Vohra, H., Zhang, Y., Nowosad, C. R., Schiepers, A., Corcoran, L. M., Toellner, K. M., Polo, J. M., Meyer-Hermann, M., Victora, G. D., & Vinuesa, C. G. (2019). Class-Switch Recombination Occurs Infrequently in Germinal Centers. Immunity, 51(2), 337-350.e7. https://doi.org/10.1016/j.immuni.2019.07.001

@article{7ee8c2d11f9c4779b81aa577af905353,

title = "Class-Switch Recombination Occurs Infrequently in Germinal Centers",

abstract = "Germinal centers (GCs) have long been considered sites in which Ig class-switch recombination (CSR) is favored. Roco et al. show that CSR occurs during the initial T cell:B cell interaction prior to GC formation and rapidly declines as B cells differentiate into GC cells and somatic hypermutation commences.",

author = "Roco, \{Jonathan A.\} and Luka Mesin and Binder, \{Sebastian C.\} and Christian Nefzger and Paula Gonzalez-Figueroa and Canete, \{Pablo F.\} and Julia Ellyard and Qian Shen and Robert, \{Philippe A.\} and Jean Cappello and Harpreet Vohra and Yang Zhang and Nowosad, \{Carla R.\} and Arien Schiepers and Corcoran, \{Lynn M.\} and Toellner, \{Kai Michael\} and Polo, \{Jose M.\} and Michael Meyer-Hermann and Victora, \{Gabriel D.\} and Vinuesa, \{Carola G.\}",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",

year = "2019",

month = aug,

day = "20",

doi = "10.1016/j.immuni.2019.07.001",

language = "English",

volume = "51",

pages = "337--350.e7",

journal = "Immunity",

issn = "1074-7613",

publisher = "Cell Press",

number = "2",

}

Roco, JA, Mesin, L, Binder, SC, Nefzger, C, Gonzalez-Figueroa, P, Canete, PF, Ellyard, J, Shen, Q, Robert, PA, Cappello, J, Vohra, H, Zhang, Y, Nowosad, CR, Schiepers, A, Corcoran, LM, Toellner, KM, Polo, JM, Meyer-Hermann, M, Victora, GD & Vinuesa, CG 2019, 'Class-Switch Recombination Occurs Infrequently in Germinal Centers', Immunity, vol. 51, no. 2, pp. 337-350.e7. https://doi.org/10.1016/j.immuni.2019.07.001

TY - JOUR

T1 - Class-Switch Recombination Occurs Infrequently in Germinal Centers

AU - Roco, Jonathan A.

AU - Mesin, Luka

AU - Binder, Sebastian C.

AU - Nefzger, Christian

AU - Gonzalez-Figueroa, Paula

AU - Canete, Pablo F.

AU - Ellyard, Julia

AU - Shen, Qian

AU - Robert, Philippe A.

AU - Cappello, Jean

AU - Vohra, Harpreet

AU - Zhang, Yang

AU - Nowosad, Carla R.

AU - Schiepers, Arien

AU - Corcoran, Lynn M.

AU - Toellner, Kai Michael

AU - Polo, Jose M.

AU - Meyer-Hermann, Michael

AU - Victora, Gabriel D.

AU - Vinuesa, Carola G.

PY - 2019/8/20

Y1 - 2019/8/20

N2 - Germinal centers (GCs) have long been considered sites in which Ig class-switch recombination (CSR) is favored. Roco et al. show that CSR occurs during the initial T cell:B cell interaction prior to GC formation and rapidly declines as B cells differentiate into GC cells and somatic hypermutation commences.

AB - Germinal centers (GCs) have long been considered sites in which Ig class-switch recombination (CSR) is favored. Roco et al. show that CSR occurs during the initial T cell:B cell interaction prior to GC formation and rapidly declines as B cells differentiate into GC cells and somatic hypermutation commences.

UR - https://www.scopus.com/pages/publications/85070659620

U2 - 10.1016/j.immuni.2019.07.001

DO - 10.1016/j.immuni.2019.07.001

M3 - Article

SN - 1074-7613

VL - 51

SP - 337-350.e7

JO - Immunity

JF - Immunity

IS - 2

ER -

Class-Switch Recombination Occurs Infrequently in Germinal Centers

Abstract

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