Cloning and mapping of platypus SOX2 and SOX14: Insights into SOX group B evolution

P. J. Kirby; P. D. Waters; M. Delbridge; M. Svartman; A. N. Stewart; K. Nagai; J. A.M. Graves

doi:10.1159/000068539

Cloning and mapping of platypus SOX2 and SOX14: Insights into SOX group B evolution

P. J. Kirby, P. D. Waters, M. Delbridge, M. Svartman, A. N. Stewart, K. Nagai, J. A.M. Graves^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

Group B SOX genes, the closest relatives to the sex-determining gene SRY, are thought to have evolved from a single ancestral SOX B by a series of duplications and translocations. The two SOX B genes SOX2 and SOX14 co-localize to chromosome 3q in humans. SOX2 and SOX14 homologues were cloned and characterized in the platypus, a monotreme mammal distantly related to man. The two genes were found to co-localize to chromosome 1q in this species. Proximity of the two related genes has therefore been conserved for 170 Myr, since humans and platypus diverged. The sequence similarity and conserved synteny of these group B genes provide clues to their origin. A simple model of SOX group B gene evolution is proposed.

Original language	English
Pages (from-to)	96-100
Number of pages	5
Journal	Cytogenetic and Genome Research
Volume	98
Issue number	1
DOIs	https://doi.org/10.1159/000068539
Publication status	Published - 2002

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title = "Cloning and mapping of platypus SOX2 and SOX14: Insights into SOX group B evolution",

abstract = "Group B SOX genes, the closest relatives to the sex-determining gene SRY, are thought to have evolved from a single ancestral SOX B by a series of duplications and translocations. The two SOX B genes SOX2 and SOX14 co-localize to chromosome 3q in humans. SOX2 and SOX14 homologues were cloned and characterized in the platypus, a monotreme mammal distantly related to man. The two genes were found to co-localize to chromosome 1q in this species. Proximity of the two related genes has therefore been conserved for 170 Myr, since humans and platypus diverged. The sequence similarity and conserved synteny of these group B genes provide clues to their origin. A simple model of SOX group B gene evolution is proposed.",

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T2 - Insights into SOX group B evolution

AU - Kirby, P. J.

AU - Waters, P. D.

AU - Delbridge, M.

AU - Svartman, M.

AU - Stewart, A. N.

AU - Nagai, K.

AU - Graves, J. A.M.

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Cloning and mapping of platypus SOX2 and SOX14: Insights into SOX group B evolution

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