Clustered Volleys Stimulus Presentation for Multifocal Objective Perimetry

Corinne F. Carle*, Andrew C. James, Faran Sabeti, Maria Kolic, Rohan W. Essex, Chris Shean, Rhiannon Jeans, Aiasha Saikal, Alice Licinio, Ted Maddess

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    6 Citations (Scopus)

    Abstract

    Purpose: Multifocal pupillographic objective perimetry (mfPOP) is being developed as an alternative to subjective threshold perimetry for the management of visual and neurological disorders. Here, we evaluate, in normal subjects, differences in signal quality between the original mfPOP method of spatially sparse Continuous stimulus presentation and the new Clustered Volleys (CVs) method. We hypothesized that the CVs method would lead to increased signal-to-noise ratios (SNRs) over the original method due to the stabilization of gain within the pupillary system. Methods: Data were collected from six separate studies where otherwise-identical pairs of mfPOP tests using either the original Continuous stimulus presentation method or the new CVs method were undertaken; 440 6-minute tests from 96 normal subjects of varying ages were included. Per-region SNRs were compared between the two methods. Results: Mean SNRs for the CVs mfPOP variants were between 35% and 57% larger than the original Continuous mfPOP variants (P < 0.001 in five of six studies). Similarly, the goodness-of-fit measure (r2 ) demonstrated large and significant fold increases of between 2.3× and 3.4× over the original method (all P < 0.001). Significant improvements in SNRs were present in all of the 88 test regions (44/eye), ranging between 8.4% and 93.7%; mean SNRs were significantly larger in 98% of test subjects. Conclusions: The CVs mfPOP stimulus presentation method produced substantial increases in signal quality over the original method. This is likely due to the stabilization of pupillary gain during stimulus presentation. Translational Relevance: These improvements increase diagnostic accuracy and have enabled shorter, 80-second mfPOP tests to be developed.

    Original languageEnglish
    Article number5
    JournalTranslational Vision Science and Technology
    Volume11
    Issue number2
    DOIs
    Publication statusPublished - Feb 2022

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