Co-evolution of the branch site and SR proteins in eukaryotes

Mireya Plass; Eneritz Agirre; Diana Reyes; Francisco Camara; Eduardo Eyras

doi:10.1016/j.tig.2008.10.004

Co-evolution of the branch site and SR proteins in eukaryotes

Mireya Plass, Eneritz Agirre, Diana Reyes, Francisco Camara, Eduardo Eyras

Research output: Contribution to journal › Article › peer-review

33 Citations (Scopus)

Abstract

Serine-arginine-rich (SR) proteins are essential for splicing in metazoans but are absent in yeast. By contrast, many fungi have SIR protein homologs with variable arginine-rich regions analogous to the arginine-serine-rich (RS) domain in metazoans. The density of RS repeats in these regions correlates with the conservation of the branch site signal, providing evidence for an ancestral origin of SR proteins and indicating that the SIR proteins and the branch site co-evolved.

Original language	English
Pages (from-to)	590-594
Number of pages	5
Journal	Trends in Genetics
Volume	24
Issue number	12
DOIs	https://doi.org/10.1016/j.tig.2008.10.004
Publication status	Published - Dec 2008
Externally published	Yes

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10.1016/j.tig.2008.10.004

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title = "Co-evolution of the branch site and SR proteins in eukaryotes",

abstract = "Serine-arginine-rich (SR) proteins are essential for splicing in metazoans but are absent in yeast. By contrast, many fungi have SIR protein homologs with variable arginine-rich regions analogous to the arginine-serine-rich (RS) domain in metazoans. The density of RS repeats in these regions correlates with the conservation of the branch site signal, providing evidence for an ancestral origin of SR proteins and indicating that the SIR proteins and the branch site co-evolved.",

keywords = "Pre-messenger-rna, Splicing enhancers, Intron, Yeast, Evolution, Contact, Signals, Domain, Snrna",

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AU - Plass, Mireya

AU - Agirre, Eneritz

AU - Reyes, Diana

AU - Camara, Francisco

AU - Eyras, Eduardo

PY - 2008/12

Y1 - 2008/12

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AB - Serine-arginine-rich (SR) proteins are essential for splicing in metazoans but are absent in yeast. By contrast, many fungi have SIR protein homologs with variable arginine-rich regions analogous to the arginine-serine-rich (RS) domain in metazoans. The density of RS repeats in these regions correlates with the conservation of the branch site signal, providing evidence for an ancestral origin of SR proteins and indicating that the SIR proteins and the branch site co-evolved.

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KW - Splicing enhancers

KW - Intron

KW - Yeast

KW - Evolution

KW - Contact

KW - Signals

KW - Domain

KW - Snrna

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VL - 24

SP - 590

EP - 594

JO - Trends in Genetics

JF - Trends in Genetics

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ER -

Co-evolution of the branch site and SR proteins in eukaryotes

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