TY - JOUR
T1 - Cognitive behavior therapy for depression in people with epilepsy
T2 - A systematic review and meta-analysis
AU - Li, Dongxu
AU - Song, Yuqi
AU - Zhang, Shuyu
AU - Qiu, Juan
AU - Zhang, Rui
AU - Wu, Jiayi
AU - Wu, Ziyan
AU - Wei, Junwen
AU - Xiang, Xuefeng
AU - Zhang, Yue
AU - Yu, Liangdong
AU - Wang, Honghan
AU - Niu, Ping
AU - Fan, Chuan
AU - Li, Xiaoming
N1 - Publisher Copyright:
© 2022 Elsevier Inc.
PY - 2023/1
Y1 - 2023/1
N2 - Background: Cognitive behavioral therapy (CBT) is the recommended treatment for depression in patients with epilepsy (PWE). However, there are no studies that calculate the effect size of CBT on depression and quality of life (QoL) in PWE. Methods: We searched seven electronic databases (PubMed, Web of Science, Embase, Cochrane Library, Clinical Trials, Ovid Medline, and PsycINFO). We included 13 studies examining CBT for depression in PWE and calculated its effect size. Results: A total of 13 studies met the criteria. After treatment, CBT improves depression in PWE (g = 0.36, 95%CI: 0.18 to 0.54, I2 = 50%), and the efficacy maintains during follow-up (g = 0.47, 95%CI: 0.04 to 0.89, I2 = 80%). Subgroup analysis has shown that individual CBT (g = 0.47, 95%CI: 0.20 to 0.73, I2 = 0%) had a greater effect size than group CBT (g = 0.30, 95%CI: 0.07 to 0.53, I2 = 62%) in the treatment of depression. Likewise, CBT has a positive effect on the QoL improvement of PWE (g = 0.34, 95%CI: 0.11 to 0.57, I2 = 64%). In controlling seizures, CBT did not differ from the control group (g = −0.06, 95%CI: −0.32 to 0.19, I2 = 0%). Conclusions: Cognitive behavioral therapy interventions were effective in improving depression and QoL in PWE, but not effective in controlling seizures. The efficacy of CBT interventions targeting seizure control seems to be uncertain.
AB - Background: Cognitive behavioral therapy (CBT) is the recommended treatment for depression in patients with epilepsy (PWE). However, there are no studies that calculate the effect size of CBT on depression and quality of life (QoL) in PWE. Methods: We searched seven electronic databases (PubMed, Web of Science, Embase, Cochrane Library, Clinical Trials, Ovid Medline, and PsycINFO). We included 13 studies examining CBT for depression in PWE and calculated its effect size. Results: A total of 13 studies met the criteria. After treatment, CBT improves depression in PWE (g = 0.36, 95%CI: 0.18 to 0.54, I2 = 50%), and the efficacy maintains during follow-up (g = 0.47, 95%CI: 0.04 to 0.89, I2 = 80%). Subgroup analysis has shown that individual CBT (g = 0.47, 95%CI: 0.20 to 0.73, I2 = 0%) had a greater effect size than group CBT (g = 0.30, 95%CI: 0.07 to 0.53, I2 = 62%) in the treatment of depression. Likewise, CBT has a positive effect on the QoL improvement of PWE (g = 0.34, 95%CI: 0.11 to 0.57, I2 = 64%). In controlling seizures, CBT did not differ from the control group (g = −0.06, 95%CI: −0.32 to 0.19, I2 = 0%). Conclusions: Cognitive behavioral therapy interventions were effective in improving depression and QoL in PWE, but not effective in controlling seizures. The efficacy of CBT interventions targeting seizure control seems to be uncertain.
KW - Cognitive behavior therapy
KW - Depression
KW - Epilepsy
KW - Meta-analysis
UR - http://www.scopus.com/inward/record.url?scp=85144771021&partnerID=8YFLogxK
U2 - 10.1016/j.yebeh.2022.109056
DO - 10.1016/j.yebeh.2022.109056
M3 - Review article
SN - 1525-5050
VL - 138
JO - Epilepsy and Behavior
JF - Epilepsy and Behavior
M1 - 109056
ER -