@article{8a8435b9e0674a5caa8485c39864d821,
title = "Comparative Molecular Analysis of Gastrointestinal Adenocarcinomas",
abstract = "We analyzed 921 adenocarcinomas of the esophagus, stomach, colon, and rectum to examine shared and distinguishing molecular characteristics of gastrointestinal tract adenocarcinomas (GIACs). Hypermutated tumors were distinct regardless of cancer type and comprised those enriched for insertions/deletions, representing microsatellite instability cases with epigenetic silencing of MLH1 in the context of CpG island methylator phenotype, plus tumors with elevated single-nucleotide variants associated with mutations in POLE. Tumors with chromosomal instability were diverse, with gastroesophageal adenocarcinomas harboring fragmented genomes associated with genomic doubling and distinct mutational signatures. We identified a group of tumors in the colon and rectum lacking hypermutation and aneuploidy termed genome stable and enriched in DNA hypermethylation and mutations in KRAS, SOX9, and PCBP1. Liu et al. analyze 921 gastrointestinal (GI) tract adenocarcinomas and find that hypermutated tumors are enriched for insertions/deletions, upper GI tumors with chromosomal instability harbor fragmented genomes, and a group of genome-stable colorectal tumors are enriched in mutations in SOX9 and PCBP1.",
keywords = "cancer, colon, colorectal, epigenetic, esophagus, genomic, methylation, rectum, stomach, tumor",
author = "Yang Liu and Sethi, {Nilay S.} and Toshinori Hinoue and Schneider, {Barbara G.} and Cherniack, {Andrew D.} and Francisco Sanchez-Vega and Seoane, {Jose A.} and Farshad Farshidfar and Reanne Bowlby and Mirazul Islam and Jaegil Kim and Walid Chatila and Rehan Akbani and Kanchi, {Rupa S.} and Rabkin, {Charles S.} and Willis, {Joseph E.} and Wang, {Kenneth K.} and McCall, {Shannon J.} and Lopa Mishra and Ojesina, {Akinyemi I.} and Susan Bullman and Pedamallu, {Chandra Sekhar} and Lazar, {Alexander J.} and Ryo Sakai and Caesar-Johnson, {Samantha J.} and Demchok, {John A.} and Ina Felau and Melpomeni Kasapi and Ferguson, {Martin L.} and Hutter, {Carolyn M.} and Sofia, {Heidi J.} and Roy Tarnuzzer and Zhining Wang and Liming Yang and Zenklusen, {Jean C.} and Zhang, {Jiashan (Julia)} and Sudha Chudamani and Jia Liu and Laxmi Lolla and Rashi Naresh and Todd Pihl and Qiang Sun and Yunhu Wan and Ye Wu and Juok Cho and Timothy DeFreitas and Scott Frazer and Nils Gehlenborg and Gad Getz and Graham Mann",
note = "Publisher Copyright: {\textcopyright} 2018 Elsevier Inc.",
year = "2018",
month = apr,
day = "9",
doi = "10.1016/j.ccell.2018.03.010",
language = "English",
volume = "33",
pages = "721--735.e8",
journal = "Cancer Cell",
issn = "1535-6108",
publisher = "Cell Press",
number = "4",
}