Comparing causality measures of fMRI data using PCA, CCA and vector autoregressive modelling

Adnan Shah*, Muhammad Usman Khalid, Abd Krim Seghouane

*Corresponding author for this work

    Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

    8 Citations (Scopus)

    Abstract

    Extracting the directional interaction between activated brain areas from functional magnetic resonance imaging (fMRI) time series measurements of their activity is a significant step in understanding the process of brain functions. In this paper, the directional interaction between fMRI time series characterizing the activity of two neuronal sites is quantified using two measures; one derived based on univariate autoregressive and autoregressive exogenous (AR/ARX) and other derived based on multivariate vector autoregressive and vector autoregressive exogenous (VAR/VARX) models. The significance and effectiveness of these measures is illustrated on both simulated and real fMRI data sets. It has been revealed that VAR modelling of the regions of interest is robust in inferring true causality compared to principal component analysis (PCA) and canonical correlation analysis (CCA) based causality methods.

    Original languageEnglish
    Title of host publication2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2012
    Pages6184-6187
    Number of pages4
    DOIs
    Publication statusPublished - 2012
    Event34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2012 - San Diego, CA, United States
    Duration: 28 Aug 20121 Sept 2012

    Publication series

    NameProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
    ISSN (Print)1557-170X

    Conference

    Conference34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2012
    Country/TerritoryUnited States
    CitySan Diego, CA
    Period28/08/121/09/12

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