Computational studies of venom peptides targeting potassium channels

Rong Chen; Shin Ho Chung

doi:10.3390/toxins7124877

Computational studies of venom peptides targeting potassium channels

Rong Chen^*, Shin Ho Chung

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

16 Citations (Scopus)

Abstract

Small peptides isolated from the venom of animals are potential scaffolds for ion channel drug discovery. This review article mainly focuses on the computational studies that have advanced our understanding of how various toxins interfere with the function of K⁺ channels. We introduce the computational tools available for the study of toxin-channel interactions. We then discuss how these computational tools have been fruitfully applied to elucidate the mechanisms of action of a wide range of venom peptides from scorpions, spiders, and sea anemone.

Original language	English
Pages (from-to)	5194-5211
Number of pages	18
Journal	Toxins
Volume	7
Issue number	12
DOIs	https://doi.org/10.3390/toxins7124877
Publication status	Published - 1 Dec 2015

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10.3390/toxins7124877

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title = "Computational studies of venom peptides targeting potassium channels",

abstract = "Small peptides isolated from the venom of animals are potential scaffolds for ion channel drug discovery. This review article mainly focuses on the computational studies that have advanced our understanding of how various toxins interfere with the function of K+ channels. We introduce the computational tools available for the study of toxin-channel interactions. We then discuss how these computational tools have been fruitfully applied to elucidate the mechanisms of action of a wide range of venom peptides from scorpions, spiders, and sea anemone.",

keywords = "Molecular dynamics, Molecular modeling, Peptide toxins, Potassium channels",

author = "Rong Chen and Chung, {Shin Ho}",

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AB - Small peptides isolated from the venom of animals are potential scaffolds for ion channel drug discovery. This review article mainly focuses on the computational studies that have advanced our understanding of how various toxins interfere with the function of K+ channels. We introduce the computational tools available for the study of toxin-channel interactions. We then discuss how these computational tools have been fruitfully applied to elucidate the mechanisms of action of a wide range of venom peptides from scorpions, spiders, and sea anemone.

KW - Molecular dynamics

KW - Molecular modeling

KW - Peptide toxins

KW - Potassium channels

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U2 - 10.3390/toxins7124877

DO - 10.3390/toxins7124877

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Computational studies of venom peptides targeting potassium channels

Abstract

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