Consecutive gold(I)-catalyzed cyclization reactions of o -(buta-1,3-diyn-1-yl-)-substituted N-aryl ureas: A one-pot synthesis of pyrimido[1,6- a ]indol-1(2 H)-ones and related systems

Phillip P. Sharp; Martin G. Banwell; Jens Renner; Klaas Lohmann; Anthony C. Willis

doi:10.1021/ol4007986

Consecutive gold(I)-catalyzed cyclization reactions of o -(buta-1,3-diyn-1-yl-)-substituted N-aryl ureas: A one-pot synthesis of pyrimido[1,6- a ]indol-1(2 H)-ones and related systems

Phillip P. Sharp, Martin G. Banwell^*, Jens Renner, Klaas Lohmann, Anthony C. Willis

^*Corresponding author for this work

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Abstract

Treatment of readily available o-(buta-1,3-diyn-1-yl-)-substituted N-aryl ureas such as 1 with the Au(I)-catalyst 11 affords, via a twofold cyclization process, the isomeric pyrimido[1,6-a]indol-1(2H)-one 3 in good yield.

Original language	English
Pages (from-to)	2616-2619
Number of pages	4
Journal	Organic Letters
Volume	15
Issue number	11
DOIs	https://doi.org/10.1021/ol4007986
Publication status	Published - 7 Jun 2013

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title = "Consecutive gold(I)-catalyzed cyclization reactions of o -(buta-1,3-diyn-1-yl-)-substituted N-aryl ureas: A one-pot synthesis of pyrimido[1,6- a ]indol-1(2 H)-ones and related systems",

abstract = "Treatment of readily available o-(buta-1,3-diyn-1-yl-)-substituted N-aryl ureas such as 1 with the Au(I)-catalyst 11 affords, via a twofold cyclization process, the isomeric pyrimido[1,6-a]indol-1(2H)-one 3 in good yield.",

author = "Sharp, {Phillip P.} and Banwell, {Martin G.} and Jens Renner and Klaas Lohmann and Willis, {Anthony C.}",

year = "2013",

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journal = "Organic Letters",

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Consecutive gold(I)-catalyzed cyclization reactions of o -(buta-1,3-diyn-1-yl-)-substituted N-aryl ureas: A one-pot synthesis of pyrimido[1,6- a ]indol-1(2 H)-ones and related systems. / Sharp, Phillip P.; Banwell, Martin G.; Renner, Jens et al.
In: Organic Letters, Vol. 15, No. 11, 07.06.2013, p. 2616-2619.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Consecutive gold(I)-catalyzed cyclization reactions of o -(buta-1,3-diyn-1-yl-)-substituted N-aryl ureas

T2 - A one-pot synthesis of pyrimido[1,6- a ]indol-1(2 H)-ones and related systems

AU - Sharp, Phillip P.

AU - Banwell, Martin G.

AU - Renner, Jens

AU - Lohmann, Klaas

AU - Willis, Anthony C.

PY - 2013/6/7

Y1 - 2013/6/7

N2 - Treatment of readily available o-(buta-1,3-diyn-1-yl-)-substituted N-aryl ureas such as 1 with the Au(I)-catalyst 11 affords, via a twofold cyclization process, the isomeric pyrimido[1,6-a]indol-1(2H)-one 3 in good yield.

AB - Treatment of readily available o-(buta-1,3-diyn-1-yl-)-substituted N-aryl ureas such as 1 with the Au(I)-catalyst 11 affords, via a twofold cyclization process, the isomeric pyrimido[1,6-a]indol-1(2H)-one 3 in good yield.

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JO - Organic Letters

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Consecutive gold(I)-catalyzed cyclization reactions of o -(buta-1,3-diyn-1-yl-)-substituted N-aryl ureas: A one-pot synthesis of pyrimido[1,6- a ]indol-1(2 H)-ones and related systems

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