Constructing Tissuelike Complex Structures Using Cell-Laden DNA Hydrogel Bricks

Yijie Wang; Yu Shao; Xiaozhou Ma; Bini Zhou; Alan Faulkner-Jones; Wenmiao Shu; Dongsheng Liu

doi:10.1021/acsami.7b01604

Constructing Tissuelike Complex Structures Using Cell-Laden DNA Hydrogel Bricks

Yijie Wang, Yu Shao, Xiaozhou Ma, Bini Zhou, Alan Faulkner-Jones, Wenmiao Shu^*, Dongsheng Liu

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

62 Citations (Scopus)

Abstract

Tissue engineering has long been a challenge because of the difficulty of addressing the requirements that such an engineered tissue must meet. In this paper, we developed a new “brick-to-wall” based on unique properties of DNA supramolecular hydrogels to fabricate three-dimensional (3D) tissuelike structures: different cell types are encapsulated in DNA hydrogel bricks which are then combined to build 3D structures. Signal responsiveness of cells through the DNA gels was evaluated and it was discovered that the gel permits cell migration in 3D. The results demonstrated that this technology is convenient, effective and reliable for cell manipulation, and we believe that it will benefit artificial tissue fabrication and future large-scale production.

Original language	English
Pages (from-to)	12311-12315
Number of pages	5
Journal	ACS Applied Materials and Interfaces
Volume	9
Issue number	14
DOIs	https://doi.org/10.1021/acsami.7b01604
Publication status	Published - 12 Apr 2017
Externally published	Yes

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abstract = "Tissue engineering has long been a challenge because of the difficulty of addressing the requirements that such an engineered tissue must meet. In this paper, we developed a new “brick-to-wall” based on unique properties of DNA supramolecular hydrogels to fabricate three-dimensional (3D) tissuelike structures: different cell types are encapsulated in DNA hydrogel bricks which are then combined to build 3D structures. Signal responsiveness of cells through the DNA gels was evaluated and it was discovered that the gel permits cell migration in 3D. The results demonstrated that this technology is convenient, effective and reliable for cell manipulation, and we believe that it will benefit artificial tissue fabrication and future large-scale production.",

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AU - Shu, Wenmiao

AU - Liu, Dongsheng

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AB - Tissue engineering has long been a challenge because of the difficulty of addressing the requirements that such an engineered tissue must meet. In this paper, we developed a new “brick-to-wall” based on unique properties of DNA supramolecular hydrogels to fabricate three-dimensional (3D) tissuelike structures: different cell types are encapsulated in DNA hydrogel bricks which are then combined to build 3D structures. Signal responsiveness of cells through the DNA gels was evaluated and it was discovered that the gel permits cell migration in 3D. The results demonstrated that this technology is convenient, effective and reliable for cell manipulation, and we believe that it will benefit artificial tissue fabrication and future large-scale production.

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Constructing Tissuelike Complex Structures Using Cell-Laden DNA Hydrogel Bricks

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