Control of Interleukin-2 Gene Transcription: A Paradigm for Inducible, Tissue-Specific Gene Expression

Karen Bunting*, Jun Wang, M. Frances Shannon

*Corresponding author for this work

    Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

    21 Citations (Scopus)

    Abstract

    Interleukin-2 (IL-2) is a key cytokine that controls immune cell function, in particular the adaptive arm of the immune system, through its ability to control the clonal expansion and homeostasis of peripheral T cells. IL-2 is produced almost exclusively by T cells in response to antigenic stimulation and thus provides an excellent example of a cell-specific inducible gene. The mechanisms that control IL-2 gene transcription have been studied in detail for the past 20 years and our current understanding of the nature of the inducible and tissue-specific controls will be discussed.

    Original languageEnglish
    Title of host publicationInterleukins
    EditorsGerald Litwack
    Pages105-145
    Number of pages41
    DOIs
    Publication statusPublished - 2006

    Publication series

    NameVitamins and Hormones
    Volume74
    ISSN (Print)0083-6729

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