TY - JOUR
T1 - Control of transmission with two types of infection
AU - Ball, Frank
AU - Becker, Niels G.
PY - 2006/4
Y1 - 2006/4
N2 - The effectiveness of a vaccination strategy to control transmission of an infectious disease depends on the way vaccine doses are distributed to individuals in a community of households. Here we show that this dependence is more complicated when acquisition and severity of illness are determined by the size of the infecting dose, as is thought to be the case for measles and varicella. Two alternative formulations for the way vaccination changes an individual's susceptibility and infectivity show that vaccination coverage, the nature of the vaccine response and the distribution of household size also have a big impact on which strategy is more effective. These judgements are made by comparing the post-vaccination reproduction numbers corresponding to different vaccination strategies.
AB - The effectiveness of a vaccination strategy to control transmission of an infectious disease depends on the way vaccine doses are distributed to individuals in a community of households. Here we show that this dependence is more complicated when acquisition and severity of illness are determined by the size of the infecting dose, as is thought to be the case for measles and varicella. Two alternative formulations for the way vaccination changes an individual's susceptibility and infectivity show that vaccination coverage, the nature of the vaccine response and the distribution of household size also have a big impact on which strategy is more effective. These judgements are made by comparing the post-vaccination reproduction numbers corresponding to different vaccination strategies.
KW - Epidemics in a community of households
KW - Infections of varying severity
KW - Vaccination strategies
UR - http://www.scopus.com/inward/record.url?scp=33646069013&partnerID=8YFLogxK
U2 - 10.1016/j.mbs.2005.12.024
DO - 10.1016/j.mbs.2005.12.024
M3 - Article
SN - 0025-5564
VL - 200
SP - 170
EP - 187
JO - Mathematical Biosciences
JF - Mathematical Biosciences
IS - 2
ER -