Controversies in the management of gastrointestinal stromal tumors

Desmond Yip*, John Zalcberg, Stephen Ackland, Andrew P. Barbour, Jayesh Desai, Stephen Fox, Dusan Kotasek, Grant Mcarthur, B. Mark Smithers

*Corresponding author for this work

    Research output: Contribution to journalReview articlepeer-review

    11 Citations (Scopus)

    Abstract

    Major advances in the medical treatment of gastrointestinal tumors (GISTs) have improved survival for both patients with advanced disease and those diagnosed with high-risk primary tumors. The Consensus approaches to best practice management of gastrointestinal stromal tumors, published in this journal in 2008, provided guidance for the management of GIST to both clinicians and regulatory authorities. Since then, clinical trials have demonstrated the benefit of adjuvant imatinib in high-risk patients, and mature data from advanced GIST studies suggest that a small but significant proportion of patients with advanced disease can achieve long-term benefit with ongoing imatinib treatment. Other evolving management strategies include the controversial use of palliative or debulking surgery to improve outcomes in advanced GIST and the development of promising new multikinase inhibitors, such as regorafenib, which has established benefit in the third-line setting. This review provides an update of recent developments in GIST management and discusses new controversies that these advances have generated.

    Original languageEnglish
    Pages (from-to)216-227
    Number of pages12
    JournalAsia-Pacific Journal of Clinical Oncology
    Volume10
    Issue number3
    DOIs
    Publication statusPublished - Sept 2014

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