Correlation between bioluminescence and bacterial burden in passively protected mice challenged with a recombinant bioluminescent M49 group A streptococcus strain

Meru Sheel, Manisha Pandey, Michael F. Good, Michael R. Batzloff

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Streptococcus pyogenes, also known as group A streptococcus (GAS), is a human pathogen which infects people of all age groups. Previous work has reported that conformationally constrained chimeric peptide J8 protects against GAS challenge. In the current study, we demonstrate the utility of bioluminescent imaging as a rapid technique for monitoring bacterial dissemination following the passive transfer of rabbit anti-J8 antibodies to naïve mice and subsequent challenge with recombinant GAS strain M49, an emm type shown to be associated with poststreptococcal glomerular nephritis.

Original languageEnglish
Pages (from-to)127-133
Number of pages7
JournalClinical and Vaccine Immunology
Volume17
Issue number1
DOIs
Publication statusPublished - Jan 2010
Externally publishedYes

Fingerprint

Dive into the research topics of 'Correlation between bioluminescence and bacterial burden in passively protected mice challenged with a recombinant bioluminescent M49 group A streptococcus strain'. Together they form a unique fingerprint.

Cite this