TY - JOUR
T1 - Correlation between light levels and the development of deprivation myopia
AU - Karouta, Cindy
AU - Ashby, Regan Scott
N1 - Publisher Copyright:
© 2015 The Association for Research in Vision and Ophthalmology, Inc.
PY - 2015/12/9
Y1 - 2015/12/9
N2 - Methods: Experiment 1: Chicks wore translucent diffusers monocularly for a period of 7 days, with exposure to one of five light intensities (500, 10,000, 20,000, 30,000, and 40,000 lux, n = 12 per group). Experiment 2: Chickens wore translucent diffusers monocularly for 11 days and were split into three groups: (1) chicks reared under 500 lux, (2) chicks reared under 40,000 lux, and (3) chicks reared under 500 lux for the first 4 days and 40,000 lux for the remaining 7 days.Results: A significant correlation was observed between log light intensity and the development of FDM, with a lesser myopic refraction (F (28, 330) = 60.86, P < 0.0001) and shorter axial length (F (4, 20) = 8.87, P < 0.0001) seen with increasing light intensities. The progression of FDM was halted in chicks that were switched from 500 to 40,000 lux.Conclusions: The level of protection from the development of FDM increases with increasing light intensity. Daily exposure to 40,000 lux almost completely prevents the onset of FDM and, once myopia is established, halts further progression.Purpose: In chicks, daily exposure to bright light (15,000 lux) retards the development of form-deprivation myopia (FDM) by roughly 60%. This study investigated whether higher light intensities increase the amount of protection against FDM, and whether protection and light intensity are correlated. Furthermore, we examined if exposure to bright light can prevent the progression of FDM or whether it affects only the onset of experimental myopia.
AB - Methods: Experiment 1: Chicks wore translucent diffusers monocularly for a period of 7 days, with exposure to one of five light intensities (500, 10,000, 20,000, 30,000, and 40,000 lux, n = 12 per group). Experiment 2: Chickens wore translucent diffusers monocularly for 11 days and were split into three groups: (1) chicks reared under 500 lux, (2) chicks reared under 40,000 lux, and (3) chicks reared under 500 lux for the first 4 days and 40,000 lux for the remaining 7 days.Results: A significant correlation was observed between log light intensity and the development of FDM, with a lesser myopic refraction (F (28, 330) = 60.86, P < 0.0001) and shorter axial length (F (4, 20) = 8.87, P < 0.0001) seen with increasing light intensities. The progression of FDM was halted in chicks that were switched from 500 to 40,000 lux.Conclusions: The level of protection from the development of FDM increases with increasing light intensity. Daily exposure to 40,000 lux almost completely prevents the onset of FDM and, once myopia is established, halts further progression.Purpose: In chicks, daily exposure to bright light (15,000 lux) retards the development of form-deprivation myopia (FDM) by roughly 60%. This study investigated whether higher light intensities increase the amount of protection against FDM, and whether protection and light intensity are correlated. Furthermore, we examined if exposure to bright light can prevent the progression of FDM or whether it affects only the onset of experimental myopia.
KW - Eye growth
KW - Light intensity
KW - Myopia
KW - Outdoor activity
UR - http://www.scopus.com/inward/record.url?scp=84921287394&partnerID=8YFLogxK
U2 - 10.1167/iovs.14-15499
DO - 10.1167/iovs.14-15499
M3 - Article
SN - 0146-0404
VL - 56
SP - 299
EP - 309
JO - Investigative Ophthalmology and Visual Science
JF - Investigative Ophthalmology and Visual Science
IS - 1
ER -