Cortical inhibitory deficits in Huntington's disease are not influenced by gender

April L. Philpott; Tarrant D.R. Cummins; Neil W. Bailey; Andrew Churchyard; Paul B. Fitzgerald; Nellie Georgiou-Karistianis

doi:10.1016/j.pscychresns.2016.04.018

Cortical inhibitory deficits in Huntington's disease are not influenced by gender

April L. Philpott, Tarrant D.R. Cummins, Neil W. Bailey, Andrew Churchyard, Paul B. Fitzgerald, Nellie Georgiou-Karistianis^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Huntington's disease (HD) affects GABA-mediated inhibitory circuitry in the cortex. As there is evidence that sex hormones affect GABAergic function, we investigated whether gender modulates GABA-related pathophysiological changes in HD. Fifteen premanifest HD, 11 symptomatic HD and 16 healthy control participants were assessed with paired-pulse transcranial magnetic stimulation applied to the primary motor cortex. Cortical inhibition was significantly reduced in symptomatic HD, compared with premanifest HD and controls. There was reduced inhibition in females overall, but no Group-by-Sex interaction. These findings suggest that sex hormones do not exert a direct influence on the mechanisms underpinning cortical inhibitory deficits in HD.

Original language	English
Pages (from-to)	1-4
Number of pages	4
Journal	Psychiatry Research - Neuroimaging
Volume	257
DOIs	https://doi.org/10.1016/j.pscychresns.2016.04.018
Publication status	Published - 30 Nov 2016
Externally published	Yes

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title = "Cortical inhibitory deficits in Huntington's disease are not influenced by gender",

abstract = "Huntington's disease (HD) affects GABA-mediated inhibitory circuitry in the cortex. As there is evidence that sex hormones affect GABAergic function, we investigated whether gender modulates GABA-related pathophysiological changes in HD. Fifteen premanifest HD, 11 symptomatic HD and 16 healthy control participants were assessed with paired-pulse transcranial magnetic stimulation applied to the primary motor cortex. Cortical inhibition was significantly reduced in symptomatic HD, compared with premanifest HD and controls. There was reduced inhibition in females overall, but no Group-by-Sex interaction. These findings suggest that sex hormones do not exert a direct influence on the mechanisms underpinning cortical inhibitory deficits in HD.",

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AU - Philpott, April L.

AU - Cummins, Tarrant D.R.

AU - Bailey, Neil W.

AU - Churchyard, Andrew

AU - Fitzgerald, Paul B.

AU - Georgiou-Karistianis, Nellie

PY - 2016/11/30

Y1 - 2016/11/30

N2 - Huntington's disease (HD) affects GABA-mediated inhibitory circuitry in the cortex. As there is evidence that sex hormones affect GABAergic function, we investigated whether gender modulates GABA-related pathophysiological changes in HD. Fifteen premanifest HD, 11 symptomatic HD and 16 healthy control participants were assessed with paired-pulse transcranial magnetic stimulation applied to the primary motor cortex. Cortical inhibition was significantly reduced in symptomatic HD, compared with premanifest HD and controls. There was reduced inhibition in females overall, but no Group-by-Sex interaction. These findings suggest that sex hormones do not exert a direct influence on the mechanisms underpinning cortical inhibitory deficits in HD.

AB - Huntington's disease (HD) affects GABA-mediated inhibitory circuitry in the cortex. As there is evidence that sex hormones affect GABAergic function, we investigated whether gender modulates GABA-related pathophysiological changes in HD. Fifteen premanifest HD, 11 symptomatic HD and 16 healthy control participants were assessed with paired-pulse transcranial magnetic stimulation applied to the primary motor cortex. Cortical inhibition was significantly reduced in symptomatic HD, compared with premanifest HD and controls. There was reduced inhibition in females overall, but no Group-by-Sex interaction. These findings suggest that sex hormones do not exert a direct influence on the mechanisms underpinning cortical inhibitory deficits in HD.

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JO - Psychiatry Research - Neuroimaging

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Cortical inhibitory deficits in Huntington's disease are not influenced by gender

Abstract

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