Covalent attachment of antagonists to the α7 nicotinic acetylcholine receptor: Synthesis and reactivity of substituted maleimides

Joseph I. Ambrus, Jill I. Halliday, Nicholas Kanizaj, Nathan Absalom, Kasper Harpsøe, Thomas Balle, Mary Chebib, Malcolm D. McLeod*

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    11 Citations (Scopus)

    Abstract

    The 3-methylmaleimide congeners of the natural product methyllycaconitine (MLA) and an analogue covalently attach to functional cysteine mutants of the α7 nicotinic acetylcholine receptor (nAChR).

    Original languageEnglish
    Pages (from-to)6699-6701
    Number of pages3
    JournalChemical Communications
    Volume48
    Issue number53
    DOIs
    Publication statusPublished - 6 Jun 2012

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