TY - JOUR
T1 - CTLA-4 and its role in autoimmune thyroid disease
AU - Chistiakov, Dimitry A.
AU - Turakulov, R. I.
PY - 2003/8
Y1 - 2003/8
N2 - Autoimmune thyroid disease (AITD) occurs in two common forms: Graves' disease and Hashimoto thyroiditis. On the basis of functional and experimental data, it has been suggested that the gene encoding cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) is a candidate gene for conferring susceptibility to thyroid autoimmunity. In this review, we critically evaluate the evidence for pathogenetic involvement of CTLA-4 in the various forms of AITD and focus on the possible role of genetic variation of the CTLA4 locus. Population genetics data strongly suggest a role for the CTLA4 region in susceptibility to AITD. However, further functional studies are required to understand the significance of CTLA4 polymorphisms in the pathogenic mechanism of AITD.
AB - Autoimmune thyroid disease (AITD) occurs in two common forms: Graves' disease and Hashimoto thyroiditis. On the basis of functional and experimental data, it has been suggested that the gene encoding cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) is a candidate gene for conferring susceptibility to thyroid autoimmunity. In this review, we critically evaluate the evidence for pathogenetic involvement of CTLA-4 in the various forms of AITD and focus on the possible role of genetic variation of the CTLA4 locus. Population genetics data strongly suggest a role for the CTLA4 region in susceptibility to AITD. However, further functional studies are required to understand the significance of CTLA4 polymorphisms in the pathogenic mechanism of AITD.
UR - http://www.scopus.com/inward/record.url?scp=0042353836&partnerID=8YFLogxK
U2 - 10.1677/jme.0.0310021
DO - 10.1677/jme.0.0310021
M3 - Review article
SN - 0952-5041
VL - 31
SP - 21
EP - 36
JO - Journal of Molecular Endocrinology
JF - Journal of Molecular Endocrinology
IS - 1
ER -