TY - JOUR
T1 - CTLA-4 and multiple sclerosis
T2 - The A49G single nucleotide polymorphism shows no association with multiple sclerosis in a Southern Australian population
AU - Wray, Bradley N.
AU - Stankovich, Jim
AU - Whittock, Lucy
AU - Dwyer, Terence
AU - Ponsonby, Anne Louise
AU - van der Mei, Ingrid A.F.
AU - Taylor, Bruce
AU - Dickinson, Joanne
AU - Foote, Simon
AU - McMorran, Brendan J.
PY - 2008/5/30
Y1 - 2008/5/30
N2 - Multiple sclerosis (MS) is a chronic autoimmune disorder that causes inflammatory demyelination and axonal damage in the central nervous system (CNS). We have investigated whether the A49G single nucleotide polymorphism (SNP) genotype of the CTLA-4 gene influenced the development of MS in Southern Australians as well as the interaction of this SNP with the DRB1*15 haplotype. There were no significant (P < 0.05) associations between the A49G genotype and risk of MS, either before or after stratification for presence of the DR15 haplotype.
AB - Multiple sclerosis (MS) is a chronic autoimmune disorder that causes inflammatory demyelination and axonal damage in the central nervous system (CNS). We have investigated whether the A49G single nucleotide polymorphism (SNP) genotype of the CTLA-4 gene influenced the development of MS in Southern Australians as well as the interaction of this SNP with the DRB1*15 haplotype. There were no significant (P < 0.05) associations between the A49G genotype and risk of MS, either before or after stratification for presence of the DR15 haplotype.
KW - Cytotoxic T lymphocyte-associated antigen-4
KW - Genetic association
KW - Major histocompatibility complex
KW - Multiple sclerosis
UR - http://www.scopus.com/inward/record.url?scp=44349113575&partnerID=8YFLogxK
U2 - 10.1016/j.jneuroim.2008.02.001
DO - 10.1016/j.jneuroim.2008.02.001
M3 - Article
C2 - 18378005
AN - SCOPUS:44349113575
SN - 0165-5728
VL - 196
SP - 139
EP - 142
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
IS - 1-2
ER -