Cyclotron production of 61Cu using natural Zn & enriched 64Zn targets

A. H. Asad; S. V. Smith; S. Chan; C. M. Jeffery; L. Morandeau; R. I. Price

doi:10.1063/1.4773947

Cyclotron production of ⁶¹Cu using natural Zn & enriched ⁶⁴Zn targets

A. H. Asad^*, S. V. Smith, S. Chan, C. M. Jeffery, L. Morandeau, R. I. Price

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

10 Citations (Scopus)

Abstract

Copper-61 (⁶¹Cu) shares with ⁶⁴Cu certain advantages for PET diagnostic imaging, but has a shorter half-life (3.4hr vs. 12.7hr) and a greater probability of positron production per disintegration (61% vs. 17.9%). One important application is for in vivo imaging of hypoxic tissue. In this study ⁶¹Cu was produced using the ⁶⁴Zn(p,α) ⁶¹Cu reaction on natural Zn or enriched ⁶⁴Zn targets. The enriched ⁶⁴Zn (99.82%) was electroplated onto high purity gold or silver foils or onto thin Al discs. A typical target bombardment used 30μA; at 11.7, 14.5 or 17.6MeV over 30-60min. The ⁶¹Cu (radiochemical purity of >95%) was separated using a combination of cation and anion exchange columns. The ⁶⁴Zn target material was recovered after each run, for re-use. In a direct comparison with enriched ⁶⁴Zn-target results, ⁶¹Cu production using the cheaper ^natZn target proved to be an effective alternative.

Original language	English
Title of host publication	14th International Workshop on Targetry and Target Chemistry
Pages	91-95
Number of pages	5
DOIs	https://doi.org/10.1063/1.4773947
Publication status	Published - 2012
Event	14th International Workshop on Targetry and Target Chemistry, WTTC 2012 - Playa del Carmen, Mexico Duration: 26 Aug 2012 → 29 Aug 2012

Publication series

Name	AIP Conference Proceedings
Volume	1509
ISSN (Print)	0094-243X
ISSN (Electronic)	1551-7616

Conference

Conference	14th International Workshop on Targetry and Target Chemistry, WTTC 2012
Country/Territory	Mexico
City	Playa del Carmen
Period	26/08/12 → 29/08/12

Access to Document

10.1063/1.4773947

Cite this

@inproceedings{c37d254fe9704dbda31ba101c57fc9eb,

title = "Cyclotron production of 61Cu using natural Zn & enriched 64Zn targets",

abstract = "Copper-61 (61Cu) shares with 64Cu certain advantages for PET diagnostic imaging, but has a shorter half-life (3.4hr vs. 12.7hr) and a greater probability of positron production per disintegration (61% vs. 17.9%). One important application is for in vivo imaging of hypoxic tissue. In this study 61Cu was produced using the 64Zn(p,α) 61Cu reaction on natural Zn or enriched 64Zn targets. The enriched 64Zn (99.82%) was electroplated onto high purity gold or silver foils or onto thin Al discs. A typical target bombardment used 30μA; at 11.7, 14.5 or 17.6MeV over 30-60min. The 61Cu (radiochemical purity of >95%) was separated using a combination of cation and anion exchange columns. The 64Zn target material was recovered after each run, for re-use. In a direct comparison with enriched 64Zn-target results, 61Cu production using the cheaper natZn target proved to be an effective alternative.",

keywords = "Cu, Zn electroplating, Production, Separation",

author = "Asad, {A. H.} and Smith, {S. V.} and S. Chan and Jeffery, {C. M.} and L. Morandeau and Price, {R. I.}",

year = "2012",

doi = "10.1063/1.4773947",

language = "English",

isbn = "9780735411272",

series = "AIP Conference Proceedings",

pages = "91--95",

booktitle = "14th International Workshop on Targetry and Target Chemistry",

note = "14th International Workshop on Targetry and Target Chemistry, WTTC 2012 ; Conference date: 26-08-2012 Through 29-08-2012",

}

Asad, AH, Smith, SV, Chan, S, Jeffery, CM, Morandeau, L & Price, RI 2012, Cyclotron production of ⁶¹Cu using natural Zn & enriched ⁶⁴Zn targets. in 14th International Workshop on Targetry and Target Chemistry. AIP Conference Proceedings, vol. 1509, pp. 91-95, 14th International Workshop on Targetry and Target Chemistry, WTTC 2012, Playa del Carmen, Mexico, 26/08/12. https://doi.org/10.1063/1.4773947

TY - GEN

T1 - Cyclotron production of 61Cu using natural Zn & enriched 64Zn targets

AU - Asad, A. H.

AU - Smith, S. V.

AU - Chan, S.

AU - Jeffery, C. M.

AU - Morandeau, L.

AU - Price, R. I.

PY - 2012

Y1 - 2012

N2 - Copper-61 (61Cu) shares with 64Cu certain advantages for PET diagnostic imaging, but has a shorter half-life (3.4hr vs. 12.7hr) and a greater probability of positron production per disintegration (61% vs. 17.9%). One important application is for in vivo imaging of hypoxic tissue. In this study 61Cu was produced using the 64Zn(p,α) 61Cu reaction on natural Zn or enriched 64Zn targets. The enriched 64Zn (99.82%) was electroplated onto high purity gold or silver foils or onto thin Al discs. A typical target bombardment used 30μA; at 11.7, 14.5 or 17.6MeV over 30-60min. The 61Cu (radiochemical purity of >95%) was separated using a combination of cation and anion exchange columns. The 64Zn target material was recovered after each run, for re-use. In a direct comparison with enriched 64Zn-target results, 61Cu production using the cheaper natZn target proved to be an effective alternative.

AB - Copper-61 (61Cu) shares with 64Cu certain advantages for PET diagnostic imaging, but has a shorter half-life (3.4hr vs. 12.7hr) and a greater probability of positron production per disintegration (61% vs. 17.9%). One important application is for in vivo imaging of hypoxic tissue. In this study 61Cu was produced using the 64Zn(p,α) 61Cu reaction on natural Zn or enriched 64Zn targets. The enriched 64Zn (99.82%) was electroplated onto high purity gold or silver foils or onto thin Al discs. A typical target bombardment used 30μA; at 11.7, 14.5 or 17.6MeV over 30-60min. The 61Cu (radiochemical purity of >95%) was separated using a combination of cation and anion exchange columns. The 64Zn target material was recovered after each run, for re-use. In a direct comparison with enriched 64Zn-target results, 61Cu production using the cheaper natZn target proved to be an effective alternative.

KW - Cu

KW - Zn electroplating

KW - Production

KW - Separation

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EP - 95

BT - 14th International Workshop on Targetry and Target Chemistry

T2 - 14th International Workshop on Targetry and Target Chemistry, WTTC 2012

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