Database analysis and gene discovery in pharmacogenetics

P. Board, N. Tetlow, A. Blackburn, G. Chelvanayagam

    Research output: Contribution to journalArticlepeer-review

    4 Citations (Scopus)

    Abstract

    The global genome research effort has resulted in the creation of extensive DNA and protein sequence data-bases that are a valuable resource for the identification of new genes and polymorphic variants of enzymes of pharmacogenetic interest. Previously undescribed members of gene families with novel functions and substrate specificities can be identified by database searching and sequence alignment strategies. Since the expressed sequence tag (EST) database contains sequences from many individuals, it can be searched for evidence of polymorphisms that can significantly influence enzyme function. The different approaches to these forms of analysis are reviewed and illustrated with examples from the glutathione transferase gene family.

    Original languageEnglish
    Pages (from-to)863-867
    Number of pages5
    JournalClinical Chemistry and Laboratory Medicine
    Volume38
    Issue number9
    DOIs
    Publication statusPublished - 2000

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