DDX3X: stressing the NLRP3 inflammasome

Daniel Fox, Si Ming Man*

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    14 Citations (Scopus)


    Stress granules and inflammasomes are intracellular com- plexes that assemble in response to cellular stress signals, enabling cells to persist and perish, respectively. In a recent study published in Nature, Samir et al. identify the helicase DDX3X as a central decision maker in the formation of pro- survival stress granules or pro-death NLRP3 inflammasomes.
    Original languageEnglish
    Pages (from-to)969-970
    Number of pages2
    JournalCell Research
    Issue number12
    Publication statusPublished - 1 Dec 2019


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