DDX3X: stressing the NLRP3 inflammasome

Daniel Fox; Si Ming Man

doi:10.1038/s41422-019-0250-8

DDX3X: stressing the NLRP3 inflammasome

Daniel Fox, Si Ming Man^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

Stress granules and inflammasomes are intracellular com- plexes that assemble in response to cellular stress signals, enabling cells to persist and perish, respectively. In a recent study published in Nature, Samir et al. identify the helicase DDX3X as a central decision maker in the formation of pro- survival stress granules or pro-death NLRP3 inflammasomes.

Original language	English
Pages (from-to)	969-970
Number of pages	2
Journal	Cell Research
Volume	29
Issue number	12
DOIs	https://doi.org/10.1038/s41422-019-0250-8
Publication status	Published - 1 Dec 2019

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title = "DDX3X: stressing the NLRP3 inflammasome",

abstract = "Stress granules and inflammasomes are intracellular com- plexes that assemble in response to cellular stress signals, enabling cells to persist and perish, respectively. In a recent study published in Nature, Samir et al. identify the helicase DDX3X as a central decision maker in the formation of pro- survival stress granules or pro-death NLRP3 inflammasomes.",

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AB - Stress granules and inflammasomes are intracellular com- plexes that assemble in response to cellular stress signals, enabling cells to persist and perish, respectively. In a recent study published in Nature, Samir et al. identify the helicase DDX3X as a central decision maker in the formation of pro- survival stress granules or pro-death NLRP3 inflammasomes.

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DDX3X: stressing the NLRP3 inflammasome

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