Decreased threshold for the nitric oxide donor glyceryl trinitrate in cortisol-induced hypertension in humans

J. J. Kelly; S. H. Tam; P. M. Williamson; J. A. Whitworth

doi:10.1111/j.1440-1681.2007.04700.x

Decreased threshold for the nitric oxide donor glyceryl trinitrate in cortisol-induced hypertension in humans

J. J. Kelly, S. H. Tam, P. M. Williamson, J. A. Whitworth^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

1. Decreased nitric oxide (NO) availability is thought to be a feature of cortisol-induced hypertension in humans. 2. We hypothesized that, accordingly, the threshold for a depressor response to NO should be decreased by cortisol treatment. 3. We re-analysed data from a study of baroreflex function in normal men treated with cortisol using glyceryl trinitrate (GTN). 4. Cortisol treatment increased blood pressure and decreased the threshold dose of GTN for a fall in systolic and mean blood pressure. 5. These data support the notion that glucorticoid hypertension is associated with reduced NO bioavailability.

Original language	English
Pages (from-to)	1317-1318
Number of pages	2
Journal	Clinical and Experimental Pharmacology and Physiology
Volume	34
Issue number	12
DOIs	https://doi.org/10.1111/j.1440-1681.2007.04700.x
Publication status	Published - Dec 2007

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title = "Decreased threshold for the nitric oxide donor glyceryl trinitrate in cortisol-induced hypertension in humans",

abstract = "1. Decreased nitric oxide (NO) availability is thought to be a feature of cortisol-induced hypertension in humans. 2. We hypothesized that, accordingly, the threshold for a depressor response to NO should be decreased by cortisol treatment. 3. We re-analysed data from a study of baroreflex function in normal men treated with cortisol using glyceryl trinitrate (GTN). 4. Cortisol treatment increased blood pressure and decreased the threshold dose of GTN for a fall in systolic and mean blood pressure. 5. These data support the notion that glucorticoid hypertension is associated with reduced NO bioavailability.",

keywords = "Blood pressure, Cortisol, Glucocorticoids, Glyceryl trinitrate, Humans, Nitric oxide",

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AU - Kelly, J. J.

AU - Tam, S. H.

AU - Williamson, P. M.

AU - Whitworth, J. A.

PY - 2007/12

Y1 - 2007/12

N2 - 1. Decreased nitric oxide (NO) availability is thought to be a feature of cortisol-induced hypertension in humans. 2. We hypothesized that, accordingly, the threshold for a depressor response to NO should be decreased by cortisol treatment. 3. We re-analysed data from a study of baroreflex function in normal men treated with cortisol using glyceryl trinitrate (GTN). 4. Cortisol treatment increased blood pressure and decreased the threshold dose of GTN for a fall in systolic and mean blood pressure. 5. These data support the notion that glucorticoid hypertension is associated with reduced NO bioavailability.

AB - 1. Decreased nitric oxide (NO) availability is thought to be a feature of cortisol-induced hypertension in humans. 2. We hypothesized that, accordingly, the threshold for a depressor response to NO should be decreased by cortisol treatment. 3. We re-analysed data from a study of baroreflex function in normal men treated with cortisol using glyceryl trinitrate (GTN). 4. Cortisol treatment increased blood pressure and decreased the threshold dose of GTN for a fall in systolic and mean blood pressure. 5. These data support the notion that glucorticoid hypertension is associated with reduced NO bioavailability.

KW - Blood pressure

KW - Cortisol

KW - Glucocorticoids

KW - Glyceryl trinitrate

KW - Humans

KW - Nitric oxide

UR - https://www.scopus.com/pages/publications/35548984891

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DO - 10.1111/j.1440-1681.2007.04700.x

M3 - Article

SN - 0305-1870

VL - 34

SP - 1317

EP - 1318

JO - Clinical and Experimental Pharmacology and Physiology

JF - Clinical and Experimental Pharmacology and Physiology

IS - 12

ER -

Decreased threshold for the nitric oxide donor glyceryl trinitrate in cortisol-induced hypertension in humans

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