Dendritic cells, BAFF, and APRIL: Innate players in adaptive antibody responses

Ian C.M. MacLennan*, Carola G. Vinuesa

*Corresponding author for this work

    Research output: Contribution to journalReview articlepeer-review

    163 Citations (Scopus)

    Abstract

    The first antibody produced in bacterial or viral infection results from B cell growth as plasmablasts. Dendritic cell-derived TNF-family ligands APRIL and/or BAFF enhance plasmablast survival and differentiation to plasma cells. Expression of these ligands by dendritic cells is promoted by innate immune signals that can convert subliminal B cell activation to a productive response. While this may be lifesaving in the face of infection, it can predispose to autoantibody production.

    Original languageEnglish
    Pages (from-to)235-238
    Number of pages4
    JournalImmunity
    Volume17
    Issue number3
    DOIs
    Publication statusPublished - 1 Sept 2002

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