Dendritic cells, BAFF, and APRIL: Innate players in adaptive antibody responses

Ian C.M. MacLennan; Carola G. Vinuesa

doi:10.1016/S1074-7613(02)00398-9

Dendritic cells, BAFF, and APRIL: Innate players in adaptive antibody responses

Ian C.M. MacLennan^*, Carola G. Vinuesa

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

171 Citations (SciVal)

Abstract

The first antibody produced in bacterial or viral infection results from B cell growth as plasmablasts. Dendritic cell-derived TNF-family ligands APRIL and/or BAFF enhance plasmablast survival and differentiation to plasma cells. Expression of these ligands by dendritic cells is promoted by innate immune signals that can convert subliminal B cell activation to a productive response. While this may be lifesaving in the face of infection, it can predispose to autoantibody production.

Original language	English
Pages (from-to)	235-238
Number of pages	4
Journal	Immunity
Volume	17
Issue number	3
DOIs	https://doi.org/10.1016/S1074-7613(02)00398-9
Publication status	Published - 1 Sept 2002

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abstract = "The first antibody produced in bacterial or viral infection results from B cell growth as plasmablasts. Dendritic cell-derived TNF-family ligands APRIL and/or BAFF enhance plasmablast survival and differentiation to plasma cells. Expression of these ligands by dendritic cells is promoted by innate immune signals that can convert subliminal B cell activation to a productive response. While this may be lifesaving in the face of infection, it can predispose to autoantibody production.",

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AB - The first antibody produced in bacterial or viral infection results from B cell growth as plasmablasts. Dendritic cell-derived TNF-family ligands APRIL and/or BAFF enhance plasmablast survival and differentiation to plasma cells. Expression of these ligands by dendritic cells is promoted by innate immune signals that can convert subliminal B cell activation to a productive response. While this may be lifesaving in the face of infection, it can predispose to autoantibody production.

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Dendritic cells, BAFF, and APRIL: Innate players in adaptive antibody responses

Abstract

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