Dengue virus M protein C-terminal peptide (DVM-C) forms ion channels

A. Premkumar; C. R. Horan; P. W. Gage

doi:10.1007/s00232-005-0744-9

Dengue virus M protein C-terminal peptide (DVM-C) forms ion channels

A. Premkumar^*, C. R. Horan, P. W. Gage

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

36 Citations (Scopus)

Abstract

A chemically synthesized peptide consisting of the C-terminus of the M protein of the Dengue virus type 1 strain Singapore S275/90 (DVM-C) produced ion channel activity in artificial lipid bilayers. The channels had a variable conductance and were more permeable to sodium and potassium ions than to chloride ions and more permeable to chloride ions than to calcium ions. Hexamethylene amiloride (100 μM) and amantadine (10 μM), blocked channels formed by DVM-C. Ion channels may play an important role in the life cycle of many viruses and drugs that block these channels may prove to be useful antiviral agents.

Original language	English
Pages (from-to)	33-38
Number of pages	6
Journal	Journal of Membrane Biology
Volume	204
Issue number	1
DOIs	https://doi.org/10.1007/s00232-005-0744-9
Publication status	Published - Mar 2005

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abstract = "A chemically synthesized peptide consisting of the C-terminus of the M protein of the Dengue virus type 1 strain Singapore S275/90 (DVM-C) produced ion channel activity in artificial lipid bilayers. The channels had a variable conductance and were more permeable to sodium and potassium ions than to chloride ions and more permeable to chloride ions than to calcium ions. Hexamethylene amiloride (100 μM) and amantadine (10 μM), blocked channels formed by DVM-C. Ion channels may play an important role in the life cycle of many viruses and drugs that block these channels may prove to be useful antiviral agents.",

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AU - Horan, C. R.

AU - Gage, P. W.

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N2 - A chemically synthesized peptide consisting of the C-terminus of the M protein of the Dengue virus type 1 strain Singapore S275/90 (DVM-C) produced ion channel activity in artificial lipid bilayers. The channels had a variable conductance and were more permeable to sodium and potassium ions than to chloride ions and more permeable to chloride ions than to calcium ions. Hexamethylene amiloride (100 μM) and amantadine (10 μM), blocked channels formed by DVM-C. Ion channels may play an important role in the life cycle of many viruses and drugs that block these channels may prove to be useful antiviral agents.

AB - A chemically synthesized peptide consisting of the C-terminus of the M protein of the Dengue virus type 1 strain Singapore S275/90 (DVM-C) produced ion channel activity in artificial lipid bilayers. The channels had a variable conductance and were more permeable to sodium and potassium ions than to chloride ions and more permeable to chloride ions than to calcium ions. Hexamethylene amiloride (100 μM) and amantadine (10 μM), blocked channels formed by DVM-C. Ion channels may play an important role in the life cycle of many viruses and drugs that block these channels may prove to be useful antiviral agents.

KW - Amantadine

KW - DVM-C

KW - Dengue

KW - HMA

KW - Virus ion channels

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SP - 33

EP - 38

JO - Journal of Membrane Biology

JF - Journal of Membrane Biology

IS - 1

ER -

Dengue virus M protein C-terminal peptide (DVM-C) forms ion channels

Abstract

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