Dependence of germinal center B cells on expression of CD21/CD35 for survival

Michael B. Fischer; Siegfried Goerg; Li Ming Shen; Andrey P. Prodeus; Christopher C. Goodnow; Garnett Kelsoe; Michael C. Carroll

doi:10.1126/science.280.5363.582

Dependence of germinal center B cells on expression of CD21/CD35 for survival

Michael B. Fischer, Siegfried Goerg, Li Ming Shen, Andrey P. Prodeus, Christopher C. Goodnow, Garnett Kelsoe, Michael C. Carroll^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

240 Citations (Scopus)

Abstract

Affinity-driven selection of B lymphocytes within germinal centers is critical for the development of high-affinity memory cells and host protection. To investigate the role of the CD21/CD35 coreceptor in b cell competition for follicular retention and survival within the germinal center, either Cr2⁺ or Cr2(null) lysozyme-specific transgenic B cells were adoptively transferred into normal mice immunized with duck (DEL) or turkey (TEL) lysozyme, which bind with different affinities. In mice injected with high-affinity turkey lysozyme, Cr2(null) B cells responded by follicular retention; however, they could not survive within germinal centers. This suggests CD21 provides a signal independent of antigen that is required for survival of B cells in the germinal center.

Original language	English
Pages (from-to)	582-585
Number of pages	4
Journal	Science
Volume	280
Issue number	5363
DOIs	https://doi.org/10.1126/science.280.5363.582
Publication status	Published - 24 Apr 1998

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title = "Dependence of germinal center B cells on expression of CD21/CD35 for survival",

abstract = "Affinity-driven selection of B lymphocytes within germinal centers is critical for the development of high-affinity memory cells and host protection. To investigate the role of the CD21/CD35 coreceptor in b cell competition for follicular retention and survival within the germinal center, either Cr2+ or Cr2(null) lysozyme-specific transgenic B cells were adoptively transferred into normal mice immunized with duck (DEL) or turkey (TEL) lysozyme, which bind with different affinities. In mice injected with high-affinity turkey lysozyme, Cr2(null) B cells responded by follicular retention; however, they could not survive within germinal centers. This suggests CD21 provides a signal independent of antigen that is required for survival of B cells in the germinal center.",

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AU - Fischer, Michael B.

AU - Goerg, Siegfried

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AU - Goodnow, Christopher C.

AU - Kelsoe, Garnett

AU - Carroll, Michael C.

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Dependence of germinal center B cells on expression of CD21/CD35 for survival

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