Depression in elderly persons subject to childhood maltreatment is not modulated by corpus callosum and hippocampal loss

Karen Ritchie; Isabelle Jaussent; Florence Portet; Philippe Courtet; Alain Malafosse; Jerome Maller; Chantal Meslin; Alain Bonafé; Emmanuelle Le Bars; Nicolas Menjot De Champfleur; Sylvaine Artero; Marie Laure Ancelin

doi:10.1016/j.jad.2012.03.035

Depression in elderly persons subject to childhood maltreatment is not modulated by corpus callosum and hippocampal loss

Karen Ritchie^*, Isabelle Jaussent, Florence Portet, Philippe Courtet, Alain Malafosse, Jerome Maller, Chantal Meslin, Alain Bonafé, Emmanuelle Le Bars, Nicolas Menjot De Champfleur, Sylvaine Artero, Marie Laure Ancelin

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

Childhood adversity has been observed to engender structural changes in the hippocampus and corpus callosum associated with increased risk for depression in childhood and early adulthood. This study investigated this association in the elderly. Corpus callosum area and hippocampal volume were measured from structural MRI in 427 community dwelling elderly. Information on childhood adversity was obtained in the course of a clinical examination using a questionnaire covering multiple aspects of abuse. Multivariate analyses found a significant increase in corpus callosum area and hippocampal volume in subjects exposed to mental disorder in parents and poverty, respectively. No association was found with childhood sexual and physical abuse.

Original language	English
Pages (from-to)	294-299
Number of pages	6
Journal	Journal of Affective Disorders
Volume	141
Issue number	2-3
DOIs	https://doi.org/10.1016/j.jad.2012.03.035
Publication status	Published - 10 Dec 2012

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Ritchie, K., Jaussent, I., Portet, F., Courtet, P., Malafosse, A., Maller, J., Meslin, C., Bonafé, A., Le Bars, E., De Champfleur, N. M., Artero, S., & Ancelin, M. L. (2012). Depression in elderly persons subject to childhood maltreatment is not modulated by corpus callosum and hippocampal loss. Journal of Affective Disorders, 141(2-3), 294-299. https://doi.org/10.1016/j.jad.2012.03.035

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title = "Depression in elderly persons subject to childhood maltreatment is not modulated by corpus callosum and hippocampal loss",

abstract = "Childhood adversity has been observed to engender structural changes in the hippocampus and corpus callosum associated with increased risk for depression in childhood and early adulthood. This study investigated this association in the elderly. Corpus callosum area and hippocampal volume were measured from structural MRI in 427 community dwelling elderly. Information on childhood adversity was obtained in the course of a clinical examination using a questionnaire covering multiple aspects of abuse. Multivariate analyses found a significant increase in corpus callosum area and hippocampal volume in subjects exposed to mental disorder in parents and poverty, respectively. No association was found with childhood sexual and physical abuse.",

keywords = "Child abuse, Corpus callosum, Depression, Elderly, Hippocampus, Magnetic resonance imaging",

author = "Karen Ritchie and Isabelle Jaussent and Florence Portet and Philippe Courtet and Alain Malafosse and Jerome Maller and Chantal Meslin and Alain Bonaf{\'e} and {Le Bars}, Emmanuelle and {De Champfleur}, {Nicolas Menjot} and Sylvaine Artero and Ancelin, {Marie Laure}",

year = "2012",

month = dec,

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Ritchie, K, Jaussent, I, Portet, F, Courtet, P, Malafosse, A, Maller, J, Meslin, C, Bonafé, A, Le Bars, E, De Champfleur, NM, Artero, S & Ancelin, ML 2012, 'Depression in elderly persons subject to childhood maltreatment is not modulated by corpus callosum and hippocampal loss', Journal of Affective Disorders, vol. 141, no. 2-3, pp. 294-299. https://doi.org/10.1016/j.jad.2012.03.035

TY - JOUR

T1 - Depression in elderly persons subject to childhood maltreatment is not modulated by corpus callosum and hippocampal loss

AU - Ritchie, Karen

AU - Jaussent, Isabelle

AU - Portet, Florence

AU - Courtet, Philippe

AU - Malafosse, Alain

AU - Maller, Jerome

AU - Meslin, Chantal

AU - Bonafé, Alain

AU - Le Bars, Emmanuelle

AU - De Champfleur, Nicolas Menjot

AU - Artero, Sylvaine

AU - Ancelin, Marie Laure

PY - 2012/12/10

Y1 - 2012/12/10

N2 - Childhood adversity has been observed to engender structural changes in the hippocampus and corpus callosum associated with increased risk for depression in childhood and early adulthood. This study investigated this association in the elderly. Corpus callosum area and hippocampal volume were measured from structural MRI in 427 community dwelling elderly. Information on childhood adversity was obtained in the course of a clinical examination using a questionnaire covering multiple aspects of abuse. Multivariate analyses found a significant increase in corpus callosum area and hippocampal volume in subjects exposed to mental disorder in parents and poverty, respectively. No association was found with childhood sexual and physical abuse.

AB - Childhood adversity has been observed to engender structural changes in the hippocampus and corpus callosum associated with increased risk for depression in childhood and early adulthood. This study investigated this association in the elderly. Corpus callosum area and hippocampal volume were measured from structural MRI in 427 community dwelling elderly. Information on childhood adversity was obtained in the course of a clinical examination using a questionnaire covering multiple aspects of abuse. Multivariate analyses found a significant increase in corpus callosum area and hippocampal volume in subjects exposed to mental disorder in parents and poverty, respectively. No association was found with childhood sexual and physical abuse.

KW - Child abuse

KW - Corpus callosum

KW - Depression

KW - Elderly

KW - Hippocampus

KW - Magnetic resonance imaging

UR - http://www.scopus.com/inward/record.url?scp=84867574900&partnerID=8YFLogxK

U2 - 10.1016/j.jad.2012.03.035

DO - 10.1016/j.jad.2012.03.035

M3 - Article

SN - 0165-0327

VL - 141

SP - 294

EP - 299

JO - Journal of Affective Disorders

JF - Journal of Affective Disorders

IS - 2-3

ER -

Depression in elderly persons subject to childhood maltreatment is not modulated by corpus callosum and hippocampal loss

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