TY - JOUR
T1 - Deterioration in Renal function is associated with increased arterial stiffness
AU - Elias, Merrill F.
AU - Davey, Adam
AU - Dore, Gregory A.
AU - Gillespie, Avrum
AU - Abhayaratna, Walter P.
AU - Robbins, Michael A.
PY - 2014/2
Y1 - 2014/2
N2 - Background Higher levels of baseline pulse wave velocity (PWV) have been associated with longitudinal decline in renal function in patients with kidney disease. We examined longitudinal decline in renal function in relation to levels of PWV. We hypothesized that longitudinal decline in renal function in a community-based, nonclinic sample would be associated with higher levels of PWV. METHODS We conducted a 4-5 year longitudinal study with 482 community-living individuals free from acute stroke, dementia, and end-stage renal disease (mean age = 60.9 years; 59% women; 93.2% white; 10% with diabetes mellitus; mean estimated glomerular filtration rate (eGFR) = 79.2ml/min/1.73 m2). Multiple linear regression analyses were used to examine the association between changes in renal function (eGFR and serum creatinine) from baseline to follow-up and PWV levels at follow-up, the outcome measure. Regression coefficients were adjusted for age, sex, education, race/ethnicity, weight, activity level, mean arterial pressure, treatment of hypertension, and cardiovascular risk factors.RESULTS With adjustment for covariables, decline in renal function was associated with higher levels of PWV over a mean follow-up of 4.68 years.CONCLUSIONS Decline in renal functioning from baseline levels measured 4-5 years before measurement of PWV is related to higher levels of PWV in a community sample.
AB - Background Higher levels of baseline pulse wave velocity (PWV) have been associated with longitudinal decline in renal function in patients with kidney disease. We examined longitudinal decline in renal function in relation to levels of PWV. We hypothesized that longitudinal decline in renal function in a community-based, nonclinic sample would be associated with higher levels of PWV. METHODS We conducted a 4-5 year longitudinal study with 482 community-living individuals free from acute stroke, dementia, and end-stage renal disease (mean age = 60.9 years; 59% women; 93.2% white; 10% with diabetes mellitus; mean estimated glomerular filtration rate (eGFR) = 79.2ml/min/1.73 m2). Multiple linear regression analyses were used to examine the association between changes in renal function (eGFR and serum creatinine) from baseline to follow-up and PWV levels at follow-up, the outcome measure. Regression coefficients were adjusted for age, sex, education, race/ethnicity, weight, activity level, mean arterial pressure, treatment of hypertension, and cardiovascular risk factors.RESULTS With adjustment for covariables, decline in renal function was associated with higher levels of PWV over a mean follow-up of 4.68 years.CONCLUSIONS Decline in renal functioning from baseline levels measured 4-5 years before measurement of PWV is related to higher levels of PWV in a community sample.
KW - blood pressure
KW - cardiovascular disease
KW - chronic kidney disease
KW - estimated glomerular filtration rate
KW - hypertension
KW - pulse wave velocity
KW - renal disease.
UR - http://www.scopus.com/inward/record.url?scp=84891591763&partnerID=8YFLogxK
U2 - 10.1093/ajh/hpt179
DO - 10.1093/ajh/hpt179
M3 - Article
SN - 0895-7061
VL - 27
SP - 207
EP - 214
JO - American Journal of Hypertension
JF - American Journal of Hypertension
IS - 2
ER -