TY - JOUR
T1 - Determination of association constants of β-cyclodextrin and β-cyclodextrin-N-succinamate with drugs by high performance liquid chromatography
AU - Ashnagar, Alamdar
AU - Easton, Christopher J.
AU - Naseri, Nahid Gharib
PY - 2005
Y1 - 2005
N2 - Investigation of the Hummel and Dreyer method for the estimation of stability constants by high performance liquid chromatography (HPLC) is described. Comparison of the results obtained for binding of cimetidine (2a) and 2-(p-tolyl)ethylamine (2b) to β-cyclodextrin(1a) and β-cyclodextrin- N-succinamate (1b) by 1H NMR (300 MHz) spectroscopy and the HPLC method were studied. The results indicated that the stability constants by HPLC method are higher and more accurate, and are 431 and 470 dm3 mol -1 for (2a) and 138 and 111 dm3 mol-1 for (2b) in binding to (1a) and (1b), respectively.
AB - Investigation of the Hummel and Dreyer method for the estimation of stability constants by high performance liquid chromatography (HPLC) is described. Comparison of the results obtained for binding of cimetidine (2a) and 2-(p-tolyl)ethylamine (2b) to β-cyclodextrin(1a) and β-cyclodextrin- N-succinamate (1b) by 1H NMR (300 MHz) spectroscopy and the HPLC method were studied. The results indicated that the stability constants by HPLC method are higher and more accurate, and are 431 and 470 dm3 mol -1 for (2a) and 138 and 111 dm3 mol-1 for (2b) in binding to (1a) and (1b), respectively.
KW - Association constants
KW - High performance liquid chromatography
KW - β-Cyclodextrin
KW - β-Cyclodextrin-N- succinamate
UR - http://www.scopus.com/inward/record.url?scp=15244346522&partnerID=8YFLogxK
M3 - Article
SN - 0970-7077
VL - 17
SP - 183
EP - 190
JO - Asian Journal of Chemistry
JF - Asian Journal of Chemistry
IS - 1
ER -