TY - JOUR
T1 - Deubiquitinating enzymes
T2 - Their functions and substrate specificity
AU - Soboleva, Tatiana A.
AU - Baker, Rohan T.
PY - 2004/6
Y1 - 2004/6
N2 - Conjugation of one or more molecules of ubiquitin to target proteins can signify one of several fates, including degradation by the 26S proteasome, or trafficking via the secretory or endocytic pathways. Whereas much attention in recent years has focussed on the mechanisms of forming these different ubiquitin conjugates, far less is known about the removal of ubiquitin, which is performed by deubiquitinating enzymes (DUBs). While it has been appreciated for some 10 years that DUBs constitute large gene families in eukaryotes, and known for much longer that ubiquitination is a reversible process, information on the exact role of DUBs has been slow in coming. This review will attempt to summarise results from the last few years that shows that DUBs are an essential regulatory step of both protein degradation by the proteasome, and of other ubiquitin-dependent processes, by virtue of their ability to regulate protein ubiquitination in a target-specific manner.
AB - Conjugation of one or more molecules of ubiquitin to target proteins can signify one of several fates, including degradation by the 26S proteasome, or trafficking via the secretory or endocytic pathways. Whereas much attention in recent years has focussed on the mechanisms of forming these different ubiquitin conjugates, far less is known about the removal of ubiquitin, which is performed by deubiquitinating enzymes (DUBs). While it has been appreciated for some 10 years that DUBs constitute large gene families in eukaryotes, and known for much longer that ubiquitination is a reversible process, information on the exact role of DUBs has been slow in coming. This review will attempt to summarise results from the last few years that shows that DUBs are an essential regulatory step of both protein degradation by the proteasome, and of other ubiquitin-dependent processes, by virtue of their ability to regulate protein ubiquitination in a target-specific manner.
KW - Deubiquitinating enzyme
KW - Isopeptidase
KW - JAMM domain
KW - OTU domain
KW - Ubiquitin C-terminal hydrolase
KW - Ubiquitin-specific protease
UR - http://www.scopus.com/inward/record.url?scp=2442591389&partnerID=8YFLogxK
U2 - 10.2174/1389203043379765
DO - 10.2174/1389203043379765
M3 - Review article
SN - 1389-2037
VL - 5
SP - 191
EP - 200
JO - Current Protein and Peptide Science
JF - Current Protein and Peptide Science
IS - 3
ER -