Development of Phylodynamic Methods for Bacterial Pathogens

Danielle J. Ingle, Benjamin P. Howden, Sebastian Duchene*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

20 Citations (Scopus)

Abstract

Phylodynamic methods have been essential to understand the interplay between the evolution and epidemiology of infectious diseases. To date, the field has centered on viruses. Bacterial pathogens are seldom analyzed under such phylodynamic frameworks, due to their complex genome evolution and, until recently, a paucity of whole-genome sequence data sets with rich associated metadata. We posit that the increasing availability of bacterial genomes and epidemiological data means that the field is now ripe to lay the foundations for applying phylodynamics to bacterial pathogens. The development of new methods that integrate more complex genomic and ecological data will help to inform public heath surveillance and control strategies for bacterial pathogens that represent serious threats to human health.

Original languageEnglish
Pages (from-to)788-797
Number of pages10
JournalTrends in Microbiology
Volume29
Issue number9
DOIs
Publication statusPublished - Sept 2021

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