TY - JOUR
T1 - Diagnosis and management of endothelial disorders following haematopoietic stem cell transplantation
AU - McEwan, Ashley
AU - Greenwood, Matthew
AU - Ward, Christopher
AU - Ritchie, David
AU - Szer, Jeff
AU - Gardiner, Elizabeth
AU - Colic, Andriana
AU - Sipavicius, Julija
AU - Panek-Hudson, Yvonne
AU - Kerridge, Ian
N1 - Publisher Copyright:
© 2023 The Authors. Internal Medicine Journal published by John Wiley & Sons Australia, Ltd on behalf of Royal Australasian College of Physicians.
PY - 2023/12
Y1 - 2023/12
N2 - Haematopoietic stem cell transplantation is a mainstay of therapy for numerous malignant and nonmalignant diseases. Endothelial activation and dysfunction occur after stem cell transplantation, driven by various patient- and transplant-specific factors. This can manifest as one of the relatively uncommon endothelial injury syndromes, such as sinusoidal obstruction syndrome, transplant-associated thrombotic microangiopathy, idiopathic pneumonia syndrome, capillary leak syndrome, engraftment syndrome or posterior reversible encephalopathy syndrome. This review focuses on the pathogenesis, classification and diagnosis of these disorders, as well as provides guidance on risk mitigation and treatment.
AB - Haematopoietic stem cell transplantation is a mainstay of therapy for numerous malignant and nonmalignant diseases. Endothelial activation and dysfunction occur after stem cell transplantation, driven by various patient- and transplant-specific factors. This can manifest as one of the relatively uncommon endothelial injury syndromes, such as sinusoidal obstruction syndrome, transplant-associated thrombotic microangiopathy, idiopathic pneumonia syndrome, capillary leak syndrome, engraftment syndrome or posterior reversible encephalopathy syndrome. This review focuses on the pathogenesis, classification and diagnosis of these disorders, as well as provides guidance on risk mitigation and treatment.
KW - endothelial dysfunction
KW - endothelial injury syndrome
KW - haematopoietic stem cell transplant
KW - sinusoidal obstruction syndrome
UR - http://www.scopus.com/inward/record.url?scp=85166570613&partnerID=8YFLogxK
U2 - 10.1111/imj.16188
DO - 10.1111/imj.16188
M3 - Review article
SN - 1444-0903
VL - 53
SP - 2162
EP - 2174
JO - Internal Medicine Journal
JF - Internal Medicine Journal
IS - 12
ER -