Diagnosis and management of endothelial disorders following haematopoietic stem cell transplantation

Ashley McEwan*, Matthew Greenwood, Christopher Ward, David Ritchie, Jeff Szer, Elizabeth Gardiner, Andriana Colic, Julija Sipavicius, Yvonne Panek-Hudson, Ian Kerridge

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

2 Citations (Scopus)

Abstract

Haematopoietic stem cell transplantation is a mainstay of therapy for numerous malignant and nonmalignant diseases. Endothelial activation and dysfunction occur after stem cell transplantation, driven by various patient- and transplant-specific factors. This can manifest as one of the relatively uncommon endothelial injury syndromes, such as sinusoidal obstruction syndrome, transplant-associated thrombotic microangiopathy, idiopathic pneumonia syndrome, capillary leak syndrome, engraftment syndrome or posterior reversible encephalopathy syndrome. This review focuses on the pathogenesis, classification and diagnosis of these disorders, as well as provides guidance on risk mitigation and treatment.

Original languageEnglish
Pages (from-to)2162-2174
Number of pages13
JournalInternal Medicine Journal
Volume53
Issue number12
DOIs
Publication statusPublished - Dec 2023

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