Diagnostics in Waldenström’s macroglobulinemia: a consensus statement of the European Consortium for Waldenström’s Macroglobulinemia

Irene Dogliotti; Cristina Jiménez; Marzia Varettoni; Dipti Talaulikar; Tina Bagratuni; Martina Ferrante; José Pérez; Daniela Drandi; Noemí Puig; Milena Gilestro; María García-Álvarez; Roger Owen; Wojciech Jurczak; Alessandra Tedeschi; Veronique Leblond; Efstathios Kastritis; Marie José Kersten; Shirley D’Sa; Michal Kaščák; Wolfgang Willenbacher; Aldo M. Roccaro; Stephanie Poulain; Pierre Morel; Charalampia Kyriakou; Falko Fend; Josephine M.I. Vos; Meletios A. Dimopoulos; Christian Buske; Simone Ferrero; Ramón García-Sanz

doi:10.1038/s41375-022-01762-3

Diagnostics in Waldenström’s macroglobulinemia: a consensus statement of the European Consortium for Waldenström’s Macroglobulinemia

Irene Dogliotti, Cristina Jiménez^*, Marzia Varettoni, Dipti Talaulikar, Tina Bagratuni, Martina Ferrante, José Pérez, Daniela Drandi, Noemí Puig, Milena Gilestro, María García-Álvarez, Roger Owen, Wojciech Jurczak, Alessandra Tedeschi, Veronique Leblond, Efstathios Kastritis, Marie José Kersten, Shirley D’Sa, Michal Kaščák, Wolfgang WillenbacherAldo M. Roccaro, Stephanie Poulain, Pierre Morel, Charalampia Kyriakou, Falko Fend, Josephine M.I. Vos, Meletios A. Dimopoulos, Christian Buske, Simone Ferrero, Ramón García-Sanz

^*Corresponding author for this work

School of Medicine and Psychology

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

The diagnosis of Waldenström’s macroglobulinemia (WM), an IgM-associated lymphoplasmacytic lymphoma, can be challenging due to the different forms of disease presentation. Furthermore, in recent years, WM has witnessed remarkable progress on the diagnostic front, as well as a deeper understanding of the disease biology, which has affected clinical practice. This, together with the increasing variety of tools and techniques available, makes it necessary to have a practical guidance for clinicians to perform the initial evaluation of patients with WM. In this paper, we present the consensus recommendations and laboratory requirements for the diagnosis of WM developed by the European Consortium of Waldenström’s Macroglobulinemia (ECWM), for both clinical practice as well as the research/academical setting. We provide the procedures for multiparametric flow cytometry, fluorescence in situ hybridization and molecular tests, and with this offer guidance for a standardized diagnostic work-up and methodological workflow of patients with IgM monoclonal gammopathy of uncertain significance, asymptomatic and symptomatic WM.

Original language	English
Pages (from-to)	388-395
Number of pages	8
Journal	Leukemia
Volume	37
Issue number	2
DOIs	https://doi.org/10.1038/s41375-022-01762-3
Publication status	Published - Feb 2023

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Dogliotti, I., Jiménez, C., Varettoni, M., Talaulikar, D., Bagratuni, T., Ferrante, M., Pérez, J., Drandi, D., Puig, N., Gilestro, M., García-Álvarez, M., Owen, R., Jurczak, W., Tedeschi, A., Leblond, V., Kastritis, E., Kersten, M. J., D’Sa, S., Kaščák, M., ... García-Sanz, R. (2023). Diagnostics in Waldenström’s macroglobulinemia: a consensus statement of the European Consortium for Waldenström’s Macroglobulinemia. Leukemia, 37(2), 388-395. https://doi.org/10.1038/s41375-022-01762-3

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title = "Diagnostics in Waldenstr{\"o}m{\textquoteright}s macroglobulinemia: a consensus statement of the European Consortium for Waldenstr{\"o}m{\textquoteright}s Macroglobulinemia",

abstract = "The diagnosis of Waldenstr{\"o}m{\textquoteright}s macroglobulinemia (WM), an IgM-associated lymphoplasmacytic lymphoma, can be challenging due to the different forms of disease presentation. Furthermore, in recent years, WM has witnessed remarkable progress on the diagnostic front, as well as a deeper understanding of the disease biology, which has affected clinical practice. This, together with the increasing variety of tools and techniques available, makes it necessary to have a practical guidance for clinicians to perform the initial evaluation of patients with WM. In this paper, we present the consensus recommendations and laboratory requirements for the diagnosis of WM developed by the European Consortium of Waldenstr{\"o}m{\textquoteright}s Macroglobulinemia (ECWM), for both clinical practice as well as the research/academical setting. We provide the procedures for multiparametric flow cytometry, fluorescence in situ hybridization and molecular tests, and with this offer guidance for a standardized diagnostic work-up and methodological workflow of patients with IgM monoclonal gammopathy of uncertain significance, asymptomatic and symptomatic WM.",

author = "Irene Dogliotti and Cristina Jim{\'e}nez and Marzia Varettoni and Dipti Talaulikar and Tina Bagratuni and Martina Ferrante and Jos{\'e} P{\'e}rez and Daniela Drandi and Noem{\'i} Puig and Milena Gilestro and Mar{\'i}a Garc{\'i}a-{\'A}lvarez and Roger Owen and Wojciech Jurczak and Alessandra Tedeschi and Veronique Leblond and Efstathios Kastritis and Kersten, {Marie Jos{\'e}} and Shirley D{\textquoteright}Sa and Michal Ka{\v s}{\v c}{\'a}k and Wolfgang Willenbacher and Roccaro, {Aldo M.} and Stephanie Poulain and Pierre Morel and Charalampia Kyriakou and Falko Fend and Vos, {Josephine M.I.} and Dimopoulos, {Meletios A.} and Christian Buske and Simone Ferrero and Ram{\'o}n Garc{\'i}a-Sanz",

note = "Publisher Copyright: {\textcopyright} 2022, The Author(s).",

year = "2023",

month = feb,

doi = "10.1038/s41375-022-01762-3",

language = "English",

volume = "37",

pages = "388--395",

journal = "Leukemia",

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Dogliotti, I, Jiménez, C, Varettoni, M, Talaulikar, D, Bagratuni, T, Ferrante, M, Pérez, J, Drandi, D, Puig, N, Gilestro, M, García-Álvarez, M, Owen, R, Jurczak, W, Tedeschi, A, Leblond, V, Kastritis, E, Kersten, MJ, D’Sa, S, Kaščák, M, Willenbacher, W, Roccaro, AM, Poulain, S, Morel, P, Kyriakou, C, Fend, F, Vos, JMI, Dimopoulos, MA, Buske, C, Ferrero, S & García-Sanz, R 2023, 'Diagnostics in Waldenström’s macroglobulinemia: a consensus statement of the European Consortium for Waldenström’s Macroglobulinemia', Leukemia, vol. 37, no. 2, pp. 388-395. https://doi.org/10.1038/s41375-022-01762-3

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T1 - Diagnostics in Waldenström’s macroglobulinemia

T2 - a consensus statement of the European Consortium for Waldenström’s Macroglobulinemia

AU - Dogliotti, Irene

AU - Jiménez, Cristina

AU - Varettoni, Marzia

AU - Talaulikar, Dipti

AU - Bagratuni, Tina

AU - Ferrante, Martina

AU - Pérez, José

AU - Drandi, Daniela

AU - Puig, Noemí

AU - Gilestro, Milena

AU - García-Álvarez, María

AU - Owen, Roger

AU - Jurczak, Wojciech

AU - Tedeschi, Alessandra

AU - Leblond, Veronique

AU - Kastritis, Efstathios

AU - Kersten, Marie José

AU - D’Sa, Shirley

AU - Kaščák, Michal

AU - Willenbacher, Wolfgang

AU - Roccaro, Aldo M.

AU - Poulain, Stephanie

AU - Morel, Pierre

AU - Kyriakou, Charalampia

AU - Fend, Falko

AU - Vos, Josephine M.I.

AU - Dimopoulos, Meletios A.

AU - Buske, Christian

AU - Ferrero, Simone

AU - García-Sanz, Ramón

PY - 2023/2

Y1 - 2023/2

N2 - The diagnosis of Waldenström’s macroglobulinemia (WM), an IgM-associated lymphoplasmacytic lymphoma, can be challenging due to the different forms of disease presentation. Furthermore, in recent years, WM has witnessed remarkable progress on the diagnostic front, as well as a deeper understanding of the disease biology, which has affected clinical practice. This, together with the increasing variety of tools and techniques available, makes it necessary to have a practical guidance for clinicians to perform the initial evaluation of patients with WM. In this paper, we present the consensus recommendations and laboratory requirements for the diagnosis of WM developed by the European Consortium of Waldenström’s Macroglobulinemia (ECWM), for both clinical practice as well as the research/academical setting. We provide the procedures for multiparametric flow cytometry, fluorescence in situ hybridization and molecular tests, and with this offer guidance for a standardized diagnostic work-up and methodological workflow of patients with IgM monoclonal gammopathy of uncertain significance, asymptomatic and symptomatic WM.

AB - The diagnosis of Waldenström’s macroglobulinemia (WM), an IgM-associated lymphoplasmacytic lymphoma, can be challenging due to the different forms of disease presentation. Furthermore, in recent years, WM has witnessed remarkable progress on the diagnostic front, as well as a deeper understanding of the disease biology, which has affected clinical practice. This, together with the increasing variety of tools and techniques available, makes it necessary to have a practical guidance for clinicians to perform the initial evaluation of patients with WM. In this paper, we present the consensus recommendations and laboratory requirements for the diagnosis of WM developed by the European Consortium of Waldenström’s Macroglobulinemia (ECWM), for both clinical practice as well as the research/academical setting. We provide the procedures for multiparametric flow cytometry, fluorescence in situ hybridization and molecular tests, and with this offer guidance for a standardized diagnostic work-up and methodological workflow of patients with IgM monoclonal gammopathy of uncertain significance, asymptomatic and symptomatic WM.

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U2 - 10.1038/s41375-022-01762-3

DO - 10.1038/s41375-022-01762-3

M3 - Article

SN - 0887-6924

VL - 37

SP - 388

EP - 395

JO - Leukemia

JF - Leukemia

IS - 2

ER -

Diagnostics in Waldenström’s macroglobulinemia: a consensus statement of the European Consortium for Waldenström’s Macroglobulinemia

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