Dialysis cells for controlled DNA: Drug binding studies

K. J. Sanders; H. Wiles; A. Rodger

doi:10.1039/b005972m

Dialysis cells for controlled DNA: Drug binding studies

K. J. Sanders^*, H. Wiles, A. Rodger

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

An efficient small volume accurate dialysis system has been designed, built and tested for proflavine binding to DNA based upon the side by side design used in the Franz diffusion cell. In a typical experiment 3 cm³ of DNA solution is added to one side and 3 cm³ of ligand to the other with a dialysis membrane between the two sides of 1 cm in diameter, thereby minimizing the area of dialysis membrane that the solutions are in contact with.

Original language	English
Pages (from-to)	852-854
Number of pages	3
Journal	Analyst
Volume	126
Issue number	6
DOIs	https://doi.org/10.1039/b005972m
Publication status	Published - 2001
Externally published	Yes

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title = "Dialysis cells for controlled DNA: Drug binding studies",

abstract = "An efficient small volume accurate dialysis system has been designed, built and tested for proflavine binding to DNA based upon the side by side design used in the Franz diffusion cell. In a typical experiment 3 cm3 of DNA solution is added to one side and 3 cm3 of ligand to the other with a dialysis membrane between the two sides of 1 cm in diameter, thereby minimizing the area of dialysis membrane that the solutions are in contact with.",

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AB - An efficient small volume accurate dialysis system has been designed, built and tested for proflavine binding to DNA based upon the side by side design used in the Franz diffusion cell. In a typical experiment 3 cm3 of DNA solution is added to one side and 3 cm3 of ligand to the other with a dialysis membrane between the two sides of 1 cm in diameter, thereby minimizing the area of dialysis membrane that the solutions are in contact with.

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Dialysis cells for controlled DNA: Drug binding studies

Abstract

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