Differences in Intrinsic Tubulin Dynamic Properties Contribute to Spindle Length Control in Xenopus Species

William G. Hirst; Abin Biswas; Kishore K. Mahalingan; Simone Reber

doi:10.1016/j.cub.2020.03.067

Differences in Intrinsic Tubulin Dynamic Properties Contribute to Spindle Length Control in Xenopus Species

William G. Hirst, Abin Biswas, Kishore K. Mahalingan, Simone Reber^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

Hirst et al. show that microtubules assembled from tubulins of two closely related frogs, Xenopus laevis and X. tropicalis, display different dynamic instability parameters in vitro. Computational simulations and spindle assembly assays show that differences in tubulin-dependent microtubule dynamics are sufficient to tune spindle mass and length.

Original language	English
Pages (from-to)	2184-2190.e5
Journal	Current Biology
Volume	30
Issue number	11
DOIs	https://doi.org/10.1016/j.cub.2020.03.067
Publication status	Published - 8 Jun 2020

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title = "Differences in Intrinsic Tubulin Dynamic Properties Contribute to Spindle Length Control in Xenopus Species",

abstract = "Hirst et al. show that microtubules assembled from tubulins of two closely related frogs, Xenopus laevis and X. tropicalis, display different dynamic instability parameters in vitro. Computational simulations and spindle assembly assays show that differences in tubulin-dependent microtubule dynamics are sufficient to tune spindle mass and length.",

keywords = "Xenopus, microtubule dynamics, spindle length, spindle scaling, tubulin",

author = "Hirst, {William G.} and Abin Biswas and Mahalingan, {Kishore K.} and Simone Reber",

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AU - Hirst, William G.

AU - Biswas, Abin

AU - Mahalingan, Kishore K.

AU - Reber, Simone

PY - 2020/6/8

Y1 - 2020/6/8

N2 - Hirst et al. show that microtubules assembled from tubulins of two closely related frogs, Xenopus laevis and X. tropicalis, display different dynamic instability parameters in vitro. Computational simulations and spindle assembly assays show that differences in tubulin-dependent microtubule dynamics are sufficient to tune spindle mass and length.

AB - Hirst et al. show that microtubules assembled from tubulins of two closely related frogs, Xenopus laevis and X. tropicalis, display different dynamic instability parameters in vitro. Computational simulations and spindle assembly assays show that differences in tubulin-dependent microtubule dynamics are sufficient to tune spindle mass and length.

KW - Xenopus

KW - microtubule dynamics

KW - spindle length

KW - spindle scaling

KW - tubulin

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VL - 30

SP - 2184-2190.e5

JO - Current Biology

JF - Current Biology

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Differences in Intrinsic Tubulin Dynamic Properties Contribute to Spindle Length Control in Xenopus Species

Abstract

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