TY - JOUR
T1 - Differential gene expression in the developing human macula
T2 - Microarray analysis using rare tissue samples
AU - Kozulin, Peter
AU - Provis, Jan M.
PY - 2009/12
Y1 - 2009/12
N2 - The macula is a unique and important region in the primate retina that achieves high resolution and color vision in the central visual field. We recently reported data obtained from microarray analysis of gene expression in the macula of the human fetal retina (Kozulin et al., Mol Vis 15:45-59, 1). In this paper, we describe the preliminary analyses undertaken to visualize differences and verify comparability of the replicates used in that study, report the differential expression of other gene families obtained from the analysis, and show the reproducibility of our findings in several gene families by quantitative real-time PCR.
AB - The macula is a unique and important region in the primate retina that achieves high resolution and color vision in the central visual field. We recently reported data obtained from microarray analysis of gene expression in the macula of the human fetal retina (Kozulin et al., Mol Vis 15:45-59, 1). In this paper, we describe the preliminary analyses undertaken to visualize differences and verify comparability of the replicates used in that study, report the differential expression of other gene families obtained from the analysis, and show the reproducibility of our findings in several gene families by quantitative real-time PCR.
KW - Macula, Gene expression, Microarray, Axon guidance, Angiogenesis, Cell adhesion molecules
UR - http://www.scopus.com/inward/record.url?scp=76849089481&partnerID=8YFLogxK
U2 - 10.1007/s12177-009-9039-1
DO - 10.1007/s12177-009-9039-1
M3 - Article
SN - 1936-8445
VL - 2
SP - 176
EP - 189
JO - Journal of Ocular Biology, Diseases, and Informatics
JF - Journal of Ocular Biology, Diseases, and Informatics
IS - 4
ER -