Differential Scanning Fluorimetry as Part of a Biophysical Screening Cascade

Duncan E. Scott, Christina Spry, Christopher Abell

    Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

    Abstract

    Differential scanning fluorimetry or thermal shift (TS) has emerged in recent years as a high-throughput method for screening compounds. In this chapter we discuss the relationship between thermal shifts and the affinity of ligands and other thermodynamic parameters.
    Original languageEnglish
    Title of host publicationFragment-based Drug Discovery: Lessons and Outlook
    EditorsD. A. Erlanson and W. Jahnke
    Place of PublicationWeinhem, Germany
    PublisherWiley-VCH Verlag GmbH
    Pages139-172
    Volume1
    ISBN (Print)9783527337750
    DOIs
    Publication statusPublished - 2016

    Publication series

    Name
    Number47
    Volume2015-January

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