TY - JOUR
T1 - Diffusivelike Motions in a Solvent-Free Protein-Polymer Hybrid
AU - Schirò, Giorgio
AU - Fichou, Yann
AU - Brogan, Alex P.S.
AU - Sessions, Richard
AU - Lohstroh, Wiebke
AU - Zamponi, Michaela
AU - Schneider, Gerald J.
AU - Gallat, François Xavier
AU - Paciaroni, Alessandro
AU - Tobias, Douglas J.
AU - Perriman, Adam
AU - Weik, Martin
N1 - Publisher Copyright:
© 2021 American Physical Society.
PY - 2021/2/25
Y1 - 2021/2/25
N2 - The interaction between proteins and hydration water stabilizes protein structure and promotes functional dynamics, with water translational motions enabling protein flexibility. Engineered solvent-free protein-polymer hybrids have been shown to preserve protein structure, function, and dynamics. Here, we used neutron scattering, protein and polymer perdeuteration, and molecular dynamics simulations to explore how a polymer dynamically replaces water. Even though relaxation rates and vibrational properties are strongly modified in polymer coated compared to hydrated proteins, liquidlike polymer dynamics appear to plasticize the conjugated protein in a qualitatively similar way as do hydration-water translational motions.
AB - The interaction between proteins and hydration water stabilizes protein structure and promotes functional dynamics, with water translational motions enabling protein flexibility. Engineered solvent-free protein-polymer hybrids have been shown to preserve protein structure, function, and dynamics. Here, we used neutron scattering, protein and polymer perdeuteration, and molecular dynamics simulations to explore how a polymer dynamically replaces water. Even though relaxation rates and vibrational properties are strongly modified in polymer coated compared to hydrated proteins, liquidlike polymer dynamics appear to plasticize the conjugated protein in a qualitatively similar way as do hydration-water translational motions.
UR - https://www.scopus.com/pages/publications/85102410562
UR - https://journals-aps-org.virtual.anu.edu.au/prl/pdf/10.1103/PhysRevLett.126.088102
UR - https://anu.primo.exlibrisgroup.com/permalink/61ANU_INST/1fctj4n/cdi_proquest_miscellaneous_2501259134
U2 - 10.1103/PhysRevLett.126.088102
DO - 10.1103/PhysRevLett.126.088102
M3 - Article
C2 - 33709739
AN - SCOPUS:85102410562
SN - 0031-9007
VL - 126
JO - Physical Review Letters
JF - Physical Review Letters
IS - 8
M1 - 088102
ER -