Direct transcriptional control of the Arabidopsis immune receptor FLS2 by the ethylene-dependent transcription factors EIN3 and EIL1

Freddy Boutrot; Cécile Segonzac; Katherine N. Chang; Hong Qiao; Joseph R. Ecker; Cyril Zipfel; John P. Rathjen

doi:10.1073/pnas.1003347107

Direct transcriptional control of the Arabidopsis immune receptor FLS2 by the ethylene-dependent transcription factors EIN3 and EIL1

Freddy Boutrot, Cécile Segonzac, Katherine N. Chang, Hong Qiao, Joseph R. Ecker, Cyril Zipfel^*, John P. Rathjen

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

184 Citations (Scopus)

Abstract

In plant innate immunity, the leucine-rich repeat receptor kinase FLS2 recognizes the bacterial pathogen-associated molecular pattern (PAMP) flagellin. The molecular mechanisms underlying PAMP perception are not fully understood. Here, we reveal that the gaseous phytohormone ethylene is an integral part of PAMP-triggered immunity. Plants mutated in the key ethylene-signaling protein EIN2 are impaired in all FLS2-mediated responses, correlating with reduced FLS2 transcription and protein accumulation. The EIN3 and EIN3-like transcription factors, which depend on EIN2 activity for their accumulation, directly control FLS2 expression. Our results reveal a direct role for ethylene in regulation of an innate immune receptor.

Original language	English
Pages (from-to)	14502-14507
Number of pages	6
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	107
Issue number	32
DOIs	https://doi.org/10.1073/pnas.1003347107
Publication status	Published - 10 Aug 2010

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Boutrot, F., Segonzac, C., Chang, K. N., Qiao, H., Ecker, J. R., Zipfel, C., & Rathjen, J. P. (2010). Direct transcriptional control of the Arabidopsis immune receptor FLS2 by the ethylene-dependent transcription factors EIN3 and EIL1. Proceedings of the National Academy of Sciences of the United States of America, 107(32), 14502-14507. https://doi.org/10.1073/pnas.1003347107

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title = "Direct transcriptional control of the Arabidopsis immune receptor FLS2 by the ethylene-dependent transcription factors EIN3 and EIL1",

abstract = "In plant innate immunity, the leucine-rich repeat receptor kinase FLS2 recognizes the bacterial pathogen-associated molecular pattern (PAMP) flagellin. The molecular mechanisms underlying PAMP perception are not fully understood. Here, we reveal that the gaseous phytohormone ethylene is an integral part of PAMP-triggered immunity. Plants mutated in the key ethylene-signaling protein EIN2 are impaired in all FLS2-mediated responses, correlating with reduced FLS2 transcription and protein accumulation. The EIN3 and EIN3-like transcription factors, which depend on EIN2 activity for their accumulation, directly control FLS2 expression. Our results reveal a direct role for ethylene in regulation of an innate immune receptor.",

keywords = "Innate immunity, Receptor kinase",

author = "Freddy Boutrot and C{\'e}cile Segonzac and Chang, {Katherine N.} and Hong Qiao and Ecker, {Joseph R.} and Cyril Zipfel and Rathjen, {John P.}",

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Boutrot, F, Segonzac, C, Chang, KN, Qiao, H, Ecker, JR, Zipfel, C & Rathjen, JP 2010, 'Direct transcriptional control of the Arabidopsis immune receptor FLS2 by the ethylene-dependent transcription factors EIN3 and EIL1', Proceedings of the National Academy of Sciences of the United States of America, vol. 107, no. 32, pp. 14502-14507. https://doi.org/10.1073/pnas.1003347107

Direct transcriptional control of the Arabidopsis immune receptor FLS2 by the ethylene-dependent transcription factors EIN3 and EIL1. / Boutrot, Freddy; Segonzac, Cécile; Chang, Katherine N. et al.
In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, No. 32, 10.08.2010, p. 14502-14507.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Direct transcriptional control of the Arabidopsis immune receptor FLS2 by the ethylene-dependent transcription factors EIN3 and EIL1

AU - Boutrot, Freddy

AU - Segonzac, Cécile

AU - Chang, Katherine N.

AU - Qiao, Hong

AU - Ecker, Joseph R.

AU - Zipfel, Cyril

AU - Rathjen, John P.

PY - 2010/8/10

Y1 - 2010/8/10

N2 - In plant innate immunity, the leucine-rich repeat receptor kinase FLS2 recognizes the bacterial pathogen-associated molecular pattern (PAMP) flagellin. The molecular mechanisms underlying PAMP perception are not fully understood. Here, we reveal that the gaseous phytohormone ethylene is an integral part of PAMP-triggered immunity. Plants mutated in the key ethylene-signaling protein EIN2 are impaired in all FLS2-mediated responses, correlating with reduced FLS2 transcription and protein accumulation. The EIN3 and EIN3-like transcription factors, which depend on EIN2 activity for their accumulation, directly control FLS2 expression. Our results reveal a direct role for ethylene in regulation of an innate immune receptor.

AB - In plant innate immunity, the leucine-rich repeat receptor kinase FLS2 recognizes the bacterial pathogen-associated molecular pattern (PAMP) flagellin. The molecular mechanisms underlying PAMP perception are not fully understood. Here, we reveal that the gaseous phytohormone ethylene is an integral part of PAMP-triggered immunity. Plants mutated in the key ethylene-signaling protein EIN2 are impaired in all FLS2-mediated responses, correlating with reduced FLS2 transcription and protein accumulation. The EIN3 and EIN3-like transcription factors, which depend on EIN2 activity for their accumulation, directly control FLS2 expression. Our results reveal a direct role for ethylene in regulation of an innate immune receptor.

KW - Innate immunity

KW - Receptor kinase

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DO - 10.1073/pnas.1003347107

M3 - Article

SN - 0027-8424

VL - 107

SP - 14502

EP - 14507

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

IS - 32

ER -

Direct transcriptional control of the Arabidopsis immune receptor FLS2 by the ethylene-dependent transcription factors EIN3 and EIL1

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