Discrete Self-Assembled Metallo-Foldamers with Heteroleptic Sequence Specificity

Dan Preston*

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    16 Citations (Scopus)

    Abstract

    Discrete and structurally diverse foldamer sequences are constructed in both natural and abiotic systems primarily using inert connectivity with irreversible organic covalent bonds, serving to preserve the identity of the sequence. The formation of sequences under thermodynamic control using labile coordination bonds would be attractive for synthetic ease and modular capability, but this presents issues regarding sequence preservation. Here is presented an approach integrating palladium(II) metal ions into the sequence itself, with fidelity maintained through use of complementary pairings of ligand arrangements at the metal centre. This is accomplished using sites of different denticity and/or hydrogen bonding capability. In this fashion, discrete and ordered metallo-sequences are formed as thermodynamic products in a single step, and these then fold into defined conformations due to π–π interactions between electron-rich and -poor aromatic regions of the combined componentry.

    Original languageEnglish
    Pages (from-to)20027-20035
    Number of pages9
    JournalAngewandte Chemie - International Edition
    Volume60
    Issue number36
    DOIs
    Publication statusPublished - 1 Sept 2021

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